Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics

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Biotechnology: Pharmaceutical Aspects VI

ISBN: 1441924027
ISBN 13: 9781441924025
Herausgeber: Patrick Augustijns/Marcus Brewster
Verlag: Springer Verlag GmbH
Umfang: x, 462 S., 110 s/w Illustr., 9 farbige Illustr., 462 p. 119 illus., 9 illus. in color.
Erscheinungsdatum: 29.11.2010
Auflage: 1/2007
Produktform: Kartoniert
Einband: KT

Practical handbook as well as a reference allowing readers to make effective decisions concerning the use of solvents and solvent systemsWritten by recognized experts from a number of fieldsIncludes useful decision trees, together with the scientific underpinning for their application, as well as trends in the use of solvent systems and a balance of current viewsUseful to both the novice and experienced researcher and to scientists at all developmental stages from early discovery to late pharmaceutical operations

Artikelnummer: 963060 Kategorie:

Beschreibung

InhaltsangabePrinciples of Solubility.- Ionic Equilibria and the pH Dependence of Solubility.- Solvent Systems for Crystallization and Polymorph Selection.- Solubility Issues in Early Discovery and HTS.- Practical Aspects of Solubility Determination in Pharmaceutical Preformulation.- Biorelevant Dissolution Media.- Selection of Solvent Systems for Membrane-, Cell- and Tissue-Based Permeability Assessment.- The Use of Solubilizing Excipients and Approaches to Generate Toxicology Vehicles for Contemporary Drug Pipelines.- Solubilizing Vehicles for Oral Formulation Development.- Solubilizing Systems for Parenteral Formulation Development-Small Molecules.- Aqueous Solubilizing Systems for Parenteral Formulation Development-Proteins.- Non-Aqueous Systems for Formulation Development-Proteins.- Pharmaceutical Solvents as Vehicles for Topical Dosage Forms.- Pharmaceutical Solvents for Pulmonary Drug Delivery.

Inhaltsverzeichnis

Introduction.- Principles of Solubility.- Ionic Equilibria and the pH Dependence of Solubility.- Solvent Systems for Crystallisation, Recrystallisation and Polymorph Selection.- Solvent Issues in Early Discovery and HTS.- Solubility Determination in Pharmaceutical Preformulation.- Systems for Determination of Bio-Relevant Dissolution.- Selection of Solvent Systems for Membrane-, Cell- and Tissue-Based Permeability Estimation.- Tox-Vehicles for Contemporary Pipelines.- Solubilizing Vehicles for Oral Formulation Development.- Solubilizing Systems for Parenteral Formulation Development - Small Molecules.- Aqueous Solubilizing Systems for Parenteral Formulation Development - Proteins.- Non-Aqueous Solubilizing Systems for Parenteral Formulation Development - Proteins.- Pharmaceutical Solvents as Vehicles for Topical Dosage Forms.- Pharmaceutical Solvents as Vehicles for Pulmonary Formulations.

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