Beschreibung
InhaltsangabePrinciples of Solubility.- Ionic Equilibria and the pH Dependence of Solubility.- Solvent Systems for Crystallization and Polymorph Selection.- Solubility Issues in Early Discovery and HTS.- Practical Aspects of Solubility Determination in Pharmaceutical Preformulation.- Biorelevant Dissolution Media.- Selection of Solvent Systems for Membrane-, Cell- and Tissue-Based Permeability Assessment.- The Use of Solubilizing Excipients and Approaches to Generate Toxicology Vehicles for Contemporary Drug Pipelines.- Solubilizing Vehicles for Oral Formulation Development.- Solubilizing Systems for Parenteral Formulation Development-Small Molecules.- Aqueous Solubilizing Systems for Parenteral Formulation Development-Proteins.- Non-Aqueous Systems for Formulation Development-Proteins.- Pharmaceutical Solvents as Vehicles for Topical Dosage Forms.- Pharmaceutical Solvents for Pulmonary Drug Delivery.
Autorenporträt
InhaltsangabePrinciples of Solubility.- Ionic Equilibria and the pH Dependence of Solubility.- Solvent Systems for Crystallization and Polymorph Selection.- Solubility Issues in Early Discovery and HTS.- Practical Aspects of Solubility Determination in Pharmaceutical Preformulation.- Biorelevant Dissolution Media.- Selection of Solvent Systems for Membrane-, Cell- and Tissue-Based Permeability Assessment.- The Use of Solubilizing Excipients and Approaches to Generate Toxicology Vehicles for Contemporary Drug Pipelines.- Solubilizing Vehicles for Oral Formulation Development.- Solubilizing Systems for Parenteral Formulation Development-Small Molecules.- Aqueous Solubilizing Systems for Parenteral Formulation Development-Proteins.- Non-Aqueous Systems for Formulation Development-Proteins.- Pharmaceutical Solvents as Vehicles for Topical Dosage Forms.- Pharmaceutical Solvents for Pulmonary Drug Delivery.