Beschreibung
This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.
Autorenporträt
InhaltsangabePart I: Innate immunity The role of cytokine responses during influenza virus pathogenesis and potential therapeutic optionsJohn R. Teijaro Innate immune sensing and response to influenza Mohan S. Maddur and Bali Pulendran The NS1 protein: a multitasking virulence factor Juan Ayllon and Adolfo Garcia-Sastre Role of NK cells in influenza infection Stacey Shultz-Cherry Host detection and the stealthy phenotype in influenza virus infectionPradyot Dash and Paul G. Thomas Part II: Vaccines and adaptive immunity Inactivated and adjuvanted influenza vaccinesGiuseppe Del Giudice and Rino Rappuoli Live attenuated influenza vaccineHong Jin and Kanta Subbarao Design of alternative live attenuated influenza virus vaccinesCourtney Finch, Weizhong Li and Daniel R. Perez Rapid production of synthetic influenza vaccinesPhilip R. Dormitzer Influenza neuraminidase as a vaccine antigenMaryna C. Eichelberger and Hongquan Wan Advances in universal influenza virus vaccine design and antibody mediated therapies based on conserved regions of the hemagglutininFlorian Krammer, Peter Palese and John Steel Structural characterization of epitopes recognized by broadly cross-reactive antibodiesPeter S. Lee and Ian A. Wilson Skin immunization with influenza vaccinesIoanna Skountzou and Richard W. Compans Mucosal immunization and adjuvants Hideki Hasegawa, Elly van Reit and Hiroshi Kida B cell responses to infection and vaccination Christopher Chiu, Ali Ellebedy, Jens Wrammert and Rafi Ahmed Memory CD4 T cells in influenzaKyra D. Zens and Donna L. Farber The effector T cell response to influenza infectionMatthew M. Hufford, Taeg S. Kim, Jie Sun and Thomas J. Braciale Part III: New antiviral discovery Antiviral Effects of Inhibiting Host Gene Expression Ralph A. Tripp and S. Mark Tompkins
Herstellerkennzeichnung:
Springer Verlag GmbH
Tiergartenstr. 17
69121 Heidelberg
DE
E-Mail: juergen.hartmann@springer.com
