Beschreibung
As the average life expectancy of many populations throughout the world increases, so to does the incidence of such age-related neurodegenerative disorders as Alzheimer's, Parkinson's, and Huntington's diseases. Rapid advances in our understanding of the molecular genetics and environmental factors that either cause or increase risk for age-related neurodegenerative disor ders have been made in the past decade. The ability to evaluate, at the cellular and molecular level, abnormalities in postmortem brain tissue from patients, when taken together with the development of valuable animal and cell-culture models of neurodegenerative disorders has allowed the identification of sequences of events within neurons that result in their demise in specific neurodegenerative disorders. Though the genetic and environmental factors that pro mote neurodegeneration may differ among disorders, shared biochemical cascades that will ultimately lead to the death of neurons have been identified. These cascades involve oxyradical production, aberrant regulation of cellular ion homeostasis and activation of a stereotyped sequence of events involving mitochondrial dysfunction and activa tion of specific proteases. Pathogenesis of Neurodegenerative Disorders provides a timely compilation of articles that encompasses fundamental mechanisms involved in neurodegenerative disorders. In addition, mechanisms that may prevent age-related neurodegenerative disorders are presented. Each chapter is written by an expert in the particular neurodegenerative disorder or mechanism or neuronal death discussed.
Inhaltsverzeichnis
Mechanisms of Neuronal Apoptosis and Excitotoxicity Mark P. Mattson Oxidative Alterations in Neurodegenerative Diseases William R. Markesbery, Thomas J. Montine, and Mark A. Lovell Parkinson''s Disease M. T. Silva and A. H. V. Schapira Scope of Trinucleotide Repeat Disorders Shoji Tsuji Mechanisms of Neuronal Death in Huntington''s Disease Vassilis E. Koliatsos, Carlos Portera-Cailliau, Gabrielle Schilling, David B. Borchelt, Mark W. Becher, and Christopher A. Ross Cellular and Molecular Mechanisms Underlying Synaptic Degeneration and Neuronal Death in Alzheimer''s Disease Mark P. Mattson, Ward A. Pedersen, and Carsten Culmsee Oxidative Stress in Down Syndrome: A Paradigm for the Pathogenesis of Neurodegenerative Disorders Rocco C. Iannello and Ismail Kola The Pathogenesis of Amyotrophic Lateral Sclerosis Stanley H. Appel and R. Glenn Smith Experimental Genetics as a Tool for Understanding Pathogenesis of ALS Philip C. Wong, Donald L. Price, and Jamuna Subramaniam Pathogenesis of Ischemic Stroke Mark P. Mattson and Carsten Culmsee Spinal-Cord Injury Isabel Klusman and Martin E. Schwab The Pathogenesis of Duchenne Muscular Dystrophy Edward A. Burton and Kay E. Davies
