Beschreibung
Chiral auxiliary based and organocatalyzed aldol reactions have been used for the asymmetric synthesis of various natural products. These reactions steps have been used in synthesizing -butyrolactone containing natural products and their analogs. An asymmetric route for one-pot synthesis of trans- and cis-4,5-disubstituted--butyrolactones via reagent sequence controlled syn- and anti- aldol reactions of N-succinyl-2-oxazolidinone are described. Mechanistic studies are discussed. Using these asymmetric syn- and anti-aldol reactions of chiral N-succinyl-2-oxazolidinones, trans-paraconic acids and cis-paraconic acids are synthesized in both of their enantiomeric forms. Enantioselective one-pot synthesis of -(hydroxyalkyl)--butyrolactones employing cross-aldol reaction catalyzed by an organocatalyst is described. Efficient routes for the asymmetric synthesis of (-)-enterolactone, natural hydroxyenterolactone and its analog utilizing organocatalytic asymmetric cross-aldol reaction and C-alkylation as the key steps are achieved. Similar routes have provided chiral intermediates, which could be converted to epi-isohydroxymatairesinol and (7R)-7-hydroxymatairesinol.
Autorenporträt
Aswini Kumar Giri: Assist. Res. Scientist: U of A, Tucson, USA. Postdoc Research: WSU, Pullman & U of A, USA. PhD: Org. Chem., IIT-Kharagpur, India. Saumen Hajra: Prof. of Chemistry, IIT-Kharagpur, India. AvH Fellow: University of Wuerzburg, Germany. Postdoc Research: North Dakota State University, USA. PhD: NCL, University of Pune, India.
Herstellerkennzeichnung:
OmniScriptum SRL
Str. Armeneasca 28/1, office 1
2012 Chisinau
MD
E-Mail: info@omniscriptum.com
