Beschreibung
The purpose of this research was to develop orodispersible tablet of fluoxetine hydrochloride. Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor drug which is used in psychiatric disorder like depression. Orodispersible tablet prepared using various concentrations (1.5%, 3% & 4.5%) of superdisintegrates like crosscarmellose, crospovidone, sodium starch glycolate by wet granulation method & sublimation method. The preformulation studies by FTIR confirmed no interactions between drug and polymers. The prepared formulations were evaluated for the pre-compression parameters & the values were within prescribed limits. The tablets prepared by wet granulation & sublimation method were evaluated for physical parameters, wetting time, disintegration time, content uniformity and in vitro dissolution.Upon comparison sublimation method was showed good results for disintegration time ,wetting time & in vitro drug release studies because sublimation of camphor increases the porosity of the tablets. The tablets prepared with crospovidone at 4.5% concentration (FS-6) by sublimation method was found to be best suitable formulation.
Autorenporträt
This is Ashok kumar Appapurapu the author of the present book. He did M.pharmacy(Pharmaceutics)and he was registered his Ph.D under JntUniversity. He has an experience in morethan 5 years in teaching and 3 years in pharmaceutical industry. He was published in morethan 10 research papers in various international and national journals.
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