Produktbild: DJ-1/PARK7 Protein

DJ-1/PARK7 Protein

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Parkinsons Disease, Cancer and Oxidative Stress-Induced Diseases, Advances in Experimental Medicine and Biology 1037

ISBN: 9811065829
ISBN 13: 9789811065828
Herausgeber: Hiroyoshi Ariga/Sanae M M Iguchi-Ariga
Verlag: Springer Verlag GmbH
Umfang: viii, 222 S., 32 s/w Illustr., 46 farbige Illustr., 222 p. 78 illus., 46 illus. in color.
Erscheinungsdatum: 04.12.2017
Auflage: 1/2018
Produktform: Gebunden/Hardback
Einband: Gebunden

This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson’s disease (PD), park7. The DJ-1 gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of DJ-1 in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases. 

Artikelnummer: 2744566 Kategorie:

Beschreibung

Covers various oxidative stress-related diseases, including cancer, neurodegenerative diseases, and type 2 diabetes as well as male infertilityBroadens the understanding of the various uses of DJ-1 such as a biomarker for diagnosis of neurodegenerative diseasesEnriches understanding of DJ-1-binding compounds which are promising drugs for various oxidative stress-related diseases

Autorenporträt

Hiroyoshi Ariga Faculty of Pharmaceutical Sciences, Hokkaido University Sapporo, Japan Sanae M.M. IguchiAriga Faculty of Agriculture, Hokkaido UniversitySapporo,Japan

Herstellerkennzeichnung:


Springer Verlag GmbH
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69121 Heidelberg
DE

E-Mail: juergen.hartmann@springer.com

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