Beschreibung
The aim of present research work was to develop gatroretentive drug delivery system of Ofloxacin, was developed using gas forming agents like sodium bicarbonate, and natural gums like Sterculia foetida. The prepared tablets evaluated in terms of their precompression parameters, physical characteristics, in vitro release, buoyancy and buoyancy lag time. The formulation optimized for different concentration of natural gums like Sterculia foetida. The results of in-vitro release studies showed that optimized formulation (F4) could sustain drug release (97.86%) for 24h & remain buoyant for 24h. The prepared tablets were evaluated in terms of their precompression parameters, physical characteristics, in-vitro release, buoyancy, buoyancy lag-time. The formulations were optimized for the different concentrations of Sterculia foetida. The results of the in-vitro release studies showed that the optimized formulation (F4) could sustain drug release (97.86%) for 24 h and remain buoyant for 24h. The optimized formulation was subjected to various kinetic release investigations and it was found that the mechanism of drug release was predominantly diffusion with a minor contribution from polymer.
Autorenporträt
Vijay Gulkari obtained his Doctoral degree in Pharmaceutical Sciences from Department of Pharmaceutical Science, Nagpur University NAGPUR. He is a Head of Department & an Associate Professor in Priyadarshini J. L. College of Pharmacy Nagpur. He is working on Standardization & validation of poly-herbal formulation by various analytical Techniques.
