Produktbild: Optimization in Drug Discovery

Optimization in Drug Discovery

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149,79 €

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In Vitro Methods, Methods in Pharmacology and Toxicology

ISBN: 1493960709
ISBN 13: 9781493960705
Herausgeber: Gary W Caldwell/Zhengyin Yan
Verlag: Humana Press
Umfang: xvii, 597 S., 64 s/w Illustr., 49 farbige Illustr., 597 p. 113 illus., 49 illus. in color.
Erscheinungsdatum: 23.08.2016
Auflage: 2/2014
Produktform: Kartoniert
Einband: Kartoniert

Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve „drug-like“ characteristics in addition to efficacy properties and good safety profiles of drug candidates.  Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.

Artikelnummer: 9753014 Kategorie:

Beschreibung

Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve "drug-like" characteristics in addition to efficacy properties and good safety profiles of drug candidates.Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.

Herstellerkennzeichnung:


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E-Mail: juergen.hartmann@springer.com

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