Produktbild: Protein Allostery in Drug Discovery

Protein Allostery in Drug Discovery

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171,19 €

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Advances in Experimental Medicine and Biology 1163

ISBN: 9811387184
ISBN 13: 9789811387180
Herausgeber: Jian Zhang/Ruth Nussinov
Verlag: Springer Verlag GmbH
Umfang: xii, 384 S., 21 s/w Illustr., 82 farbige Illustr., 384 p. 103 illus., 82 illus. in color.
Erscheinungsdatum: 20.11.2019
Auflage: 1/2020
Produktform: Gebunden/Hardback
Einband: Gebunden

The book focuses on protein allostery in drug discovery. Allosteric regulation, ‚the second secret of life‘, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery-as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc.

Artikelnummer: 7422601 Kategorie:

Beschreibung

Autorenporträt

Dr. Jian Zhang is Professor at Shanghai Jiao Tong University School of Medicine, Shanghai, China; Dr. Ruth Nussinov is Professor in the Section of Computational Structural Biology, Cancer and Inflammation Program, National Cancer Institute, USA

Herstellerkennzeichnung:


Springer Verlag GmbH
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69121 Heidelberg
DE

E-Mail: juergen.hartmann@springer.com

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