Beschreibung
The aim of this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results. Emphasis is placed on the interplay of imaging technology and probe development, since the physical properties of the imaging approach need to be closely linked with the biologic application of the probe (i.e. nanoparticles and microbubbles). Various chemical strategies are discussed and related to the biologic applications. Reporter-gene imaging is beeing addressed not only in experimental protocols, but also first clinical applications are discussed. Finally, strategies of imaging to characterize apoptosis and angiogenesis are described and discussed in the context of possible clinical translation.
Autorenporträt
InhaltsangabeIII. Amplification Strategies. Optical Methods. PET and SPECT. Magnetic Resonance.- IV. Molecular Targets and Biomarkers for Imaging.- Peptides, Multimers and Polymers. Small Molecule Receptors as Imaging Targets. Enzymes/Transporters. Phage Peptide Display.- V. Applications.- Experimental Imaging. Molecular Imaging: Gene Reporter Imaging (Protein / Protein). The Use of Ultrasound in Transfection and Transgene Expression. Magnetic Resonance of Mouse Models of Cardiac Disease.- Translational Imaging. Imaging of Apoptosis. Molecular Imaging of PET Reporter Gene Expression. Non Invasive Cell Tracking. Non-invasive Tracer Techniques to Characterize Angigogenesis. Molecular Imaging-guided Gene Therapy of Gliomas
