Beschreibung
Carvedilol, a BCS class II ß blocker drug is formulated as a SR matrix tablet with micronized drug particle. Micronization helps improve dissolution and enhances systemic absorption for BCS II drugs such as carvedilol.Direct compression method was applied to prepare tablet using PEO 301 as a release retardant polymer. The formulation was optimized by a 3 level factorial design considering amount of PEO 301 and hardness of tablet as dependent variables. In-vitro release study showed near about 100% of drug release in 12 hrs. for lowest particle size drug whereas for non-micronized drug it was less than 80%.
Autorenporträt
Bappaditya Chatterjee (PhD), a doctorate in Pharmacy from Jadavpur University, India is currently attached with Pharmaceutical Technology Dept, IIUM, Malaysia as an assistant professor with additional responsibility as the head, R&D, IKOP Sdn. Bhd. He published more than 30 articles in high impact journal in last 5 yrs.
Herstellerkennzeichnung:
BoD - Books on Demand
In de Tarpen 42
22848 Norderstedt
DE
E-Mail: info@bod.de
