Design & Evaluation of Controlled Release Matrix Tablets of Prazosin

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35,90 

Modern Management of Hypertension

ISBN: 6138387821
ISBN 13: 9786138387824
Autor: Kothari, Rajan/Sharma, Gaurav Kumar/Atul Tiwari, Pankaj Chasta
Verlag: LAP LAMBERT Academic Publishing
Umfang: 76 S.
Erscheinungsdatum: 28.04.2018
Auflage: 1/2018
Format: 0.5 x 22 x 15
Gewicht: 131 g
Produktform: Kartoniert
Einband: KT
Artikelnummer: 5095050 Kategorie:

Beschreibung

In the present study, we have prepared matrix tablet formulations using Prazocin as a model drug and Ethyl Cellulose, Two grades of Hydroxy Propyl Methyl Cellulose- HPMC-K4M & HPMC-K100M as polymers in different ratios. The developed matrix tablets were evaluated for different physical-chemical evaluations like drug content, hardness, friability, swelling index etc. All the formulations had shown the results within prescribed limits. The In vitro drug release study indicates that formulation PCF-7 containing EC, HPMC K100M in 1:2 ratio shown good release pattern for 14 hours compares to other formulations. The short-term stability study proved no change in the formulation of ageing and it indicates good stability.

Autorenporträt

Mr. Rajan Kothari, M.Pharm.(Pharmaceutics), Rajiv Gandhi University of Health Sciences, Bangalore, Karnataka, India. Assistant Professor at Faculty of Pharmaceutical Sciences, Mewar University, Gangrar, Chittorgarh-312901, Rajasthan, India

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