Beschreibung
This book covers all aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism. Special attention will be paid to methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. This book is multidisciplinary and designed to bring together experts and students from a range of research fields including biochemical engineering, physiology, microcirculation, and hematology.
Inhaltsverzeichnis
Part 1 - Near Infrared Spectroscopy Chapter 1 The Western Reserve, Edward Morley and Oxygen Chapter 2 Analysis of the Changes in the Oxidation of Brain Tissue Cytochrome c Oxidase in Traumatic Brain Injury Patients during Hypercapnoea: A Broadband NIRS Study Chapter 3 Effects of Assuming Constant Optical Scattering on Haemoglobin Concentration Measurements using NIRS during a Valsalva Manoeuvre Chapter 4 Speech Therapy Changes Blood Circulation and Oxygenation in the Brain and Muscle. A Near-Infrared Spectrophotometry Study Part 2 - Oxygen Sensors and Measurement Chapter 5 Evaluation of Lithium Naphthalocyanine (LiNc) Microcrystals for Biological EPR Oximetry Chapter 6 Challenges to Intestinal pO2 Measurement Using EPR Chapter 7 Quantification of Systemic Interference in Optical Topography Data during Frontal Lobe and Motor Cortex Activation: An Independent Component Analysis Chapter 8 Measuring Oxygen in Living Tissue: Intravascular, Interstitial and "Tissue" Oxygen Measurements Chapter 9 Cerebral Oxygenation of the Cortex and Striatum following Normobaric Hyperoxia and Mild Hypoxia in Rats by EPR Oximetry Using Multi-Probe Implantable Resonators Chapter 10 31P-MRS Studies of Melanoma Xenograft Metastatic Potential Chapter 11 Modulation of Tumor Hypoxia by Topical Formulations with Vasodilators for Enhancing Therapy Part 3 - Blood and Blood Substitutes Chapter 12 MP4, A Vasodilatory PEGylated Hemoglobin Chapter 13 Zymogen Protein C to Prevent Clotting Without Bleeding During Invasive Medical Procedures Part 4 - Tumor Biology Chapter 14 Oxygenation Status of Urogenital Tumors Chapter 15 Tumor pO2 as a Surrogate Marker to Identify Therapeutic Window during Metronomic Chemotherapy of 9L Gliomas Chapter 16 Hypoxia-induced Extracellular Acidosis Increases p-glycoprotein activity and chemoresistance in tumors in vivo via p38 signaling pathway Chapter 17 Evidence Against a Major Role for TKTL-1 in Hypoxic and Normoxic Cancer Cells Chapter 18 NMR Metabolic and Physiological Markers of Therapeutic Response Chapter 19 Characterizing Breast Cancer Mouse Xenografts with T1p-MRI: A Preliminary Study Chapter 20 Effect of AEM Energy Applicator Configuration on Magnetic Nanoparticle Mediated Hyperthermia for Breast Cancer Chapter 21 Highly Specific, NIR Fluorescent Contrast Agent with Emission Controlled by Gold Nanoparticle Part 5 - Presidential Symposium Chapter 22 Oral Pioglitazone Reduces Infarction Volume and Improves Neurologic Function Following MCAO in Rats Part 6 - Angiogenesis Chapter 23 Chronic Mild Hypoxia Ameliorates Chronic Inflammatory Activity in Myelin Oligodendrocyte Glycoprotein (MOG) Peptide Induced Experimental Autoimmune Encephalomyelitis (EAE) Chapter 24 Effect of Oxygenation on Stem-Cell Therapy for Myocardial Infarction Part 7 - Mitochondrial Metabolism Chapter 25 Regulation of Cytosolic and Mitochondrial Oxidation via Malate-Aspartate Shuttle: An Observation Using Dynamic 13C NMR Spectroscopy Chapter 26 In Vivo Assessment of Oxygen Consumption via Deuterium Magnetic Resonance Chapter 27 Elevated Mitochondrial DNA Copy Number and POL-i§ Expression but decreased Expression of TFAM in Murine Intestine following Therapeutic Dose Irradiation Chapter 28 Heterogeneity of Mitochondrial Redox State in Premalignant Pancreas in a PTEN Null Transgenic Mouse Model Chapter 29 Potential Application of 17O MRI to Human Ischemic Stroke Part 8 - Development Chapter 30 Fetal Cerebral Oxygenation: The Homeostatic Role of Vascular Adaptations to Hypoxic Stress Chapter 31 Impaired Cerebral Autoregulation Using Near-Infrared Spectroscopy and its Relation to Clinical Outcomes ...
