Dendritic Cells in Fundamental and Clinical Immunology

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Volume 3, Advances in Experimental Medicine and Biology 417

ISBN: 1475799683
ISBN 13: 9781475799682
Herausgeber: Paola Ricciardi-Castagnoli
Verlag: Springer Verlag GmbH
Umfang: xvi, 594 S., 403 s/w Illustr.
Erscheinungsdatum: 22.05.2013
Auflage: 1/1997
Produktform: Kartoniert
Einband: KT

InhaltsangabeDendritic Cell Development and Migration.- Dendritic Cell Development and Maturation.- Generation of Mature Dendritic Cells from Human Blood.- Growth and Differentiation of Human Dendritic Cells from CD34+ Progenitors.- CD34+ Hematopoietic Progenitors from Human Cord Blood Differentiate Along two Independent Dendritic Cell Pathways in Response to GM-CSF+TNF?.- Myeloid DCs Deduced from Monocytes.- Dramatic Numerical Increase of Functionally Mature Dendritic Cells in FLT3 Ligand-Treated Mice.- Selective Expression of Human Fascin (p55) by Dendritic Leukocytes.- Dendritic-Like Cells from relB Mutant Mice.- Driving Gene Expression Specifically in Dendritic Cells.- Checkpoints and Functional Stages in DC Maturation.- T Cell-Mediated Terminal Maturation of Dendritic cells.- Migration of Cultured Chimpanzee Dendritic Cells Following Intravenous and Subcutaneous Injection.- The Liver Sinusoids as a Specialized Site for Blood-Lymph Translocation of Rat Dendritic Cells.- Regulation of CD44 Isoform Expression and CD44-Mediated Signaling in Human Dendritic Cells.- Mouse Spleen Dendritic Cells.- Migration of Dendritic Cells in 3D-Collagen Lattices.- Dendritic Cells of the Murine Peyer’s Patches Colocalize with Salmonella Typhimurium Avirulent Mutants in the Subepithelial Dome.- The Role of CD11c+ Cells as Possible Candidates for Immature Dendritic Cells in the Murine Peyer’s Patches.- The Influence of Collagen, Fibronectin, and Laminin on the Maturation of Dendritic Cell Progenitors Propagated from Normal or Flt3-Ligand-Treated Mouse Liver.- Stimulation of Langerhans Cell Migration in Mice by Tumour Necrosis Factor ? and Interleukin 1?.- Langerhans Cells Require Signals from Both Tumour Necrosis Factor ? and Interleukin 1? for Migration.- ?6 Integrins are Required for Langerhans Cell Migration.- Functional Expression and Modulation of C5a Receptor (CD88) on Skin Dendritic Cells.- Unilineage Dendritic Cell Cultures Generated by Purified Human Hematopoietic Progenitor Cells.- CD14 is Expressed by Subsets of Murine Dendritic Cells and Upregulated by Lipopolysaccharide.- TGF-?1 Dependent Generation of LAG+ Dendritic Cells from CD34+ Progenitors in Serum-Free Medium.- Antigen Uptake, Processing, and Presentation.- A Newly Identified Antigen Retention Compartment in the FSDC Precursor Dendritic Cell Line.- Mannose Receptor Mediated Uptake of Antigens Strongly Enhances HLA-Class II Restricted Antigen Presentation by Cultured Dendritic Cells.- Mechanisms of Fc?RI-IgE-Facilitated Allergen Presentation by Dendritic Cells.- Localization and Intracellular Transport of MHC Class II Molecules in Bone Marrow-Derived Dendritic Cells.- Mannose Receptor Mediated Antigen Uptake and Presentation in Human Dendritic Cells.- Enhanced Antigen Presenting Cell Function Following in Vivo Priming.- Dendritic Cells from Mice Lacking the Invariant Chain Express High Levels of Membrane MHC Class II Molecules in Vivo.- T Lymphocyte Mediated Regulation of Costimulator Molecule Expression on Human Dendritic Cells.- Activation of Immature Dendritic Cells Via Membrane Sialophorin (CD43).- Processing of Exogenous Protein Antigen by Murine Dendritic Cells for Presentation to Cytotoxic T Lymphocytes.- The TH1 Lymphokine Interferon-? is a Potent Upregulator of Dendritic Cells with Phagocytic Capacity in GM-CSF Supplemented Bone Marrow Cultures.- Functional Role of CD101 on Skin Dendritic Cells.- Presentation of Tetanus Toxoid to Autologous T Cells by Dendritic Cells Generated from Human Blood.- DC and Tolerance.- The Regulation of T Cell Responses by a Subpopulation of CD8+DEC205+ Murine Dendritic Cells.- Constructing Artificial Antigen-Presenting Cells from Drosophila Cells.- Role of Dendritic Cells in Induction of Tolerance and Immunity in Vivo.- B7-2+ Low Density APCS are as Effective as B7-2? Small Resting B Cells in Inducing Specific Unresponsiveness to Minor Histocompatibility (miH) Antigen(S) in Vivo.- An Attempt to Induce Tolerance with Infusion of Donor Bone Marrow in O

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Beschreibung

These proceedings contain selected contributions from the participants to the Fourth International Symposium on Dendritic cells that was held in Venice (Lido) Italy, from Oc tober 5 to 10, 1996. The symposium was attended by more than 500 scientists coming from 24 different countries. Studies on dendritic cells (DC) have been greatly hampered by the difficulties in preparing sufficient cell numbers and in a reasonable pure form. At this meeting it has been shown that large quantities of DC can be generated from precursors in both mice and humans, and this possibility has enormously encouraged studies aimed to characterize DC physiology and DC-specific genes, and to employ DC therapeutically as adjuvants for im munization. The possibility of generating large numbers of autologous DC that can be used in the manipulation of the immune response against cancer and infectious diseases has tremendously boosted dendritic cell research and the role of DC in a number of medi cal areas has been heatedly discussed.

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