Beschreibung
The Clinical Research Institute of Montreal, inaugurated in April 1967, intro duced a new concept of organization of clinical research in teaching medical centers. Adjacent to the Hotel-Dieu Hospital, a major teaching hospital of the University of Montreal, the "professional" or career clinical investigators were grouped under one roof with common auditorium, seminar rooms, instruments rooms, cold rooms, experimental surgical rooms and illustration department, with administration, accounting division and machine shops at the service of the research workers. Besides its large multidisciplinary team working on various aspects of hyper tension, the Institute includes research teams in the following fields: 1) neuro biology and Parkinson's disease, 2) lipids and atherosclerosis, 3) molecular biology, 4) immunochemistry, 5) pituitary polypeptides and proteins, 6) nutrition and 7) clinical pharmacology of new drugs. Research is financed entirely by grants obtained from accredited agencies, mostly from the Medical Research Council of Canada. These grant monies constitute about 50 % of the entire budget of the Institute while the other half for administration, maintenance and physical facilities is financed through the support of the Ministry of Social Affairs of Quebec.
Autorenporträt
InhaltsangabeOpening Remarks: The Remarkable Story of Hypertension.- Session 1.- Effects of Sympathetic Activity and ACTH on Renin and Aldosterone Secretion.- Contrived Suppression of Renin Secretion During Sodium Depletion.- Mechanism of Increased Renin Secretion Associated with Adrenalectomy, Hemorrhage, Renal Artery Constriction, and Sodium Depletion.- A Comparison of the Effects of Various Catecholamines on Plasma Renin Activity Alone and in the Presence of Adrenergic Blocking Agents.- In Vitro Renin Release by Human Kidney Slices: Effect of Norepinephrine, Angiotensin II and I, and Aldosterone.- Summary of Discussions.- New Observations on Renin Release by the Non-Filtering Kidney.- Functional and Enzymatic Analyses of Single Juxtaglomerular Apparatuses.- Studies on the Intrarenal Action of the Renin-Angiotensin System.- Renin and Renal Function.- Structural and Ultrastructural Alterations in Mesenteric and Renal Arterioles Following Infusion of Vaso-Active Agents.- Summary of Discussions.- Session 2.- Paradoxical Response of Plasma Renin Activity to Change in Sodium Intake in Hypertensive Patients.- The Relationship between Adrenergic Nervous System and Renin in Labile Hyperkinetic Hypertension.- Effect of Upright Posture on Cyclic AMP Excretion in Control Subjects and Patients with Essential Hypertension.- Reduction of Renal Mass and Hypertension.- Stimulatory Action of Various Drugs on Plasma Renin Activity and Angiotensin II Concentration in Normals, Patients with Arterial Hypertension and Congestive Heart Failure.- Summary of Discussions.- Session 3.- Multiple Forms of Human Kidney Renin.- The Nature of Renal Renin.- The Liver and the Renin Angiotensin System: The Effects of Common Bile Duct Ligature on Blood Pressure, Juxtaglomerular Apparatus and Renin Activity in Rats.- Corticotensins: Pressor Peptides from the Kidney.- Summary of Discussions.- Session 4.- The Role of Cations, ATP and Vasoactive Substances on the Activity of Contractile Proteins of Arteries.- Electron Microscopic Study of Arterial Lesions in Experimental Hypertension.- Effects of Angiotensin II on DNA, RNA and Protein Synthesis.- Circadian Aspects of Hormone and Electrolyte Metabolism in Hypertension.- Dynamic Changes in Plasma Aldosterone and Cortisol Levels and Renin Activity in Patients with Oligosymptomatic Adrenocortical Hypertension Simulating Essential Hypertension.- Summary of Discussions.- Session 5.- Aldosterone, Deoxycorticosterone, and Corticosterone Metabolism in Benign Essential Hypertension.- Secretion, Distribution and Turnover of Aldosterone in Essential Hypertension, Primary Aldosteronism, and Hypertension Associated with Renal Artery Stenosis.- Renin and Aldosterone in the Etiology and Prognosis of Essential Hypertension: Their Relation to Vascular Complications.- Aldosterone Responses to Volume Manipulation: Normal Man, Hypertension.- Incomplete Suppression of Aldosterone Secretion and Plasma Concentration in Hypertensive Patients on High Sodium Intake.- Plasma Progesterone Levels and 18-Hydroxydeoxycorticosterone Secretion Rate in Benign Essential Hypertension in Humans.- Summary of Discussions.- Session 6.- Photoscanning of Tumors in Primary Aldosteronism: Possible Distinction from "Idiopathic" Aldosteronism.- A Review of Spironolactone Therapy in Patients with Hypertension, Aldosterone Excess and Low Plasma Renin. Increased Desoxycortico- sterone in Hypertension - Another Variant of the Mineralocorticoid Excess Syndrome.- Mineralocorticoid Hypertension: Recognition and Results of Treatment.- The Influence of Glucocorticoids and Heparin on Aldosterone Production.- Summary of Discussions.- Session 7.- Some Genetically Determined Differences between Hypertension-Prone and Hypertension-Resistant Rats.- 18-Hydroxy-11-Deoxycorticosterone (18-OH-DOC) Secretion in Experimental and Human Hypertension.- The Effect of Dietary Sodium on the Blood Pressure of Normotensive Man.- Summary of Discussions.- Session 8.- The Cortico-Medullary Zone of the Ad
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