Beschreibung
Differentiation of nervous tissue, which occurs during CNS development, was first described in detail while investigating a model of rat brain through the use of a new biomarker known as alpha-fetoprotein, AFP. During this research, another model -mouse teratocarcinoma - enabled the description of the different steps of nervous tissue formation following distinct pathological ways of CNS development. Comparing these two processes gave rise to the following conclusions: a striking convergence exists between normal and neoplastic nervous tissue development and correlates with the presence of oncoproteins such as AFP and growth factor IGF-I. These interesting observations have oriented the pursuit of one goal: stopping the neoplastic CNS development conducing to the malignant tumor - glioblastoma. From this endeavor, stemmed an efficient anti-gene strategy targeting gene of growth factor IGF-I present in brain tumor development, inducing immune anti-tumor response and consequently, increasing the median survival of glioblastoma patients up to 2 years.
Autorenporträt
Jerzy Trojan has completed his Doctorat d'Etat ès Sciences in 1981 in Paris VI University, and performed the research in neuroscience in French NIH, then in CWRU, OH, and in UNAB, Colombia. He is a co-author of 227 publications. Between 1993 and 2017 he has established cancer immunonogene therapy as a new oncology domain [Wikipedia - Gene therapy].
Herstellerkennzeichnung:
OmniScriptum SRL
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MD
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