Beschreibung
SPECIAL TOPICS I was then Director of Biological Research of a pharmaceutical company just west of the Hackensack River swamps when my collabora tors presented me with an impressive book. Its gold-embossed title read: "WHAT I KNOW ABOUT BIOLOGICAL RESEARCH by GERHARD ZBINDEN, M. D. ". Those acquainted with the subtleties of American humor will have guessed the book's content: about 700 empty pages. But I liked the idea enough to write down what I knew about my branch of biologi Ical research, drug toxicology. With gentle prodding by Dr. Parkhurst IShore of Dallas, Texas, I assembled a review on those experimental and clinical aspects of drug toxicology with which I, as an industrial toxicologist, had been most concerned with. It turned out to be a modest paper, considerably less than 700 pages, but it seemed to fill a need for others who were laboring on similar problems (Zbinden 1963). Drug toxicology has changed much since 1963 when the review ap peared. Its problems have certainly not become smaller. Scientists of many biological specialties have become interested in questions of harmful drug effects. Their input has greatly enriched the knowledge of the basic processes underlying certain forms of toxic drug reac tions. With this surge of interest and effort, extreme specialization has occurred which sometimes tended to dominate the toxicological scene.
Autorenporträt
InhaltsangabeI. Introduction.- Special Topics.- The Many Faces of Toxicology.- II. Formal Toxicology.- Toxicological Prerequisites for the Study and General Release of New Drugs.- Towards a Comprehensive and Methodical Approach to Toxicology.- Acute Toxicology.- III. Speculative Toxicology.- General Remarks.- Induction of Drug Metabolizing Enzymes.- Protein Binding.- Pyridoxal Phosphate.- IV. Comparative Toxicology.- General Remarks.- The Factor Age.- Ambient Temperature.- V. Pharmacodynamic Toxicology.- General Remarks.- Thyroid Stimulation.- VI. Symptomatic Toxicology.- General Remarks.- Oxaluria.- Acute, Interstitial, Eosinophilic Myocarditis.- Coombs Test Positivity.- VII. Systematic Toxicology.- General Remarks.- Hexachlorophene.- Hypervitaminosis.- VIII. Geographical Toxicology.- General Remarks.- Subacute, Myelo-optico Neuropathy.
Herstellerkennzeichnung:
Springer Verlag GmbH
Tiergartenstr. 17
69121 Heidelberg
DE
E-Mail: juergen.hartmann@springer.com
