Beschreibung
The papers collected in this volume were presented at the International Symposium on Hypotensive Peptides held in Flor ence, Italy, on October 25-29, 1965. The purpose of the meeting was to bring together scientists of fourteen countries ranging from the chemist to the surgeon, who usually do not speak a common language and for whom it would be quite difficult to follow the latest developments in fields allied to, but still some what removed from their basic interest. Their reports sum marized their recent progress and current achievements, and gave indication of the trend that future research on hypotensive peptides may take. Various aspects of the structure and function of brady kinin, kallidin, kallikrein, gastrin, eledoiSin, physalaemin, sub stance P, and related substances were discussed during the nine sessions. The first session was devoted to the chemistry of peptides. This was followed in loose order by reports dealing with the structure of some newer peptides, with kininogen, and with enzymes that release or inactivate peptides. Subsequently, reports on the physiological, pharmacological, pathological, and clinical importance of kinins, kallikrein, and eledoisin were presented. One entire session was devoted to substance P. At the closing session two motion pictures demonstrated the effect of the peptides on the circulation. The appendix of this volume contains the report of the international Committee on Nomenclature.
Autorenporträt
InhaltsangabeAutomated Peptide Synthesis.- Synthesis of All-D-Isomers in the Bradykinin Series.- The Search for Peptides with Specific Antibradykinin Activity.- Discussion.- Recent Developments in the Chemistry of Gastrin.- The Influence of Substitution or Omission of an Amino Group on the Hypotensive Activity of the C-Terminal Sequences of Eledoisin.- Novel Techniques for the Synthesis of Linear and Cyclic Peptides.- Polypeptides Active on Plain Muscle in the Amphibian Skin.- Isolation, Amino Acid Sequence, and Biological Activity of Phyllokinin (Br adykinyl-Isoleucyl-Tyrosine O- Sulfate), a Bradykinin-like Endecapeptide of the Skin of Phyllomedusa rohdei.- Synthetic Peptides Related to Physalaemin and Eledoisin.- Characterization of Kinins in Wasp Venom.- Studies of Bovine Plasma, Kininogen, Ornitho-kallikrein, and Ornitho-kinin.- Enzymatic Kinin Release from Kininogen and from Low- Molecular Compounds.- The Purification and Some Properties of Two Different Kallidinogens from Human Plasma.- Physiological Influence on the Liberation of Human Plasma Kinin at Low Temperatures.- Purification and Properties of Bradykininogen and of the Bradykinin-Releasing and-Destroying Enzymes in Snake Venom.- Human Salivary Kallikrein and Liberation of Colostrokinin.- Studies of the Specificity of Kinin-Forming Enzymes. The Inhibition of the Kininogenic Activity of Trypsin and Kallikreins by Model Compounds.- Demonstration of the Presence of Two Separate Kinin-Forming Systems in Human and Other Plasma.- Quantitative Studies of Kinin-Releasing Enzymes in Plasma.- Immunologic Studies of Components of the Kallikrein-Kinin System.- Kininogenases, Kininases, and Their Inhibitors.- Inactivation and Potentiation of the Effects of Bradykinin.- The RoleoftheCathepsins in the Inactivation of Plasma Kinins.- The Physiological and Pathological Role of the Kallikrein-Kallidin System.- Kallikrein and Vasodilatation in the Salivary Gland.- Further Experiments on the Role of Human Plasma Kinins as Mediators of Functional Vasodilatation in Glandular Tissues.- Effect of Bradykinin on Submandibular Salivary Gland Permeability.- A Radio Immunoassay for Bradykinin.- Self-Antagonism of Bronchoconstriction Induced by Bradykinin and Angiotensin.- The Effect of Bradykinin and Angiotensin on Ganglionic Transmission.- Polypeptide Receptor Mechanisms: Influence of pH.- Sensitization of Smooth Muscle to the Action of Plasma Kinins by Chymotrypsin.- Potentiation of the Effect of Bradykinin.- Bradykinin- Potentiating Factor.- The Influence of Intra-Arterial Infusions of Synthetic Bradykinin on Flow and Composition of Lymph in Dogs.- The Action of Hypotensive Polypeptides on the Pulmonary Arterial Pressure.- Bradykinin and Pulmonary Vascular Permeability in Isolated Blood-Perfused Rabbit Lungs.- Venoconstriction Induced by Bradykinin in the Rabbit Ear.- Cardiovascular Actions of Physalaemin.- Hemodynamic Effects of Physalaemin and of Some Synthetic Eledoisin and Physalaemin-like Polypeptides.- The Effects of Eledoisin and Bradykinin on the General and Visceral Circulation.- The Effects of Bradykinin and Substance P on the Specialized Ventricular Conducting System of Dog Heart.- Microcirculatory Effects of Polypeptides.- The Proteolytic Process in Pancreatic Disease.- Kinin Formation and Destruction in Fluid Produced by a Strangulated Segment of Ileum in the Rat.- Fibrinolysis and Vasoactive Peptides in Anaphylaxis.- Treatment of Experimental and Human Atherosclerosis with Bradykinin-Antagonist, Pyridinolcarbamate: A Preliminary Report.- Some Physiological and Pathological Roles of Kininogen and Kinins.- Bradykininogen in the Blood of Women During Pregnancy, Labor, and Puerperium.- Pharmacologically Active Peptides in Trypanosome Infections.- Possible Modes of Kinin Formation in Some Pathological States in Man.- Biochemical and Physiologic Studies of the Kinins in Carcinoid Syndrome.- Occurrence of a Polypeptide Biologically Not Distinguishable from Bradykinin in Human Pulmonary Carcinoma
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