Beschreibung
In the early twentieth century the relevance of chirality to thepharmaceutical industry was established by the fact that oneenantiomer of hyoscyamine possessed greater pharmacologicalactivity than the other. Today, most new drugs and those under development consist of asingle optically active isomer, and chirality is also becoming anissue for the agrochemical and other industries. Regulatoryagencies throughout the world are currently reviewing theimportance of chirality with regard to pharmaceutical andagrochemical products. New guidelines from such agencies have beenkey drivers for the focus on single enantiomer products in theseindustries. These scientific and regulatory developments have created the needfor a guide for workers in the pharmaceutical and chemicalindustries seeking information on chiral molecules, processes, andcommercially available chiral chemicals. Chiral Drugs is acomprehensive listing of over 2500 chiral drugs, classified bytherapeutic class, and including structures and physical propertiesfor each entry in the listing. Its companion volume, ChiralIntermediates, presents the same detailed information for over 4700commercially available chiral chemicals. The 'Chiral Pool' of readily available, relatively inexpensivechiral compounds has been expanding at a rapid rate as more andmore products are produced in large quantities at economicalprices. New developments in various technologies for isolating,preparing, and purifying chiral materials have greatly increasedthe opportunities for utilizing optically pure compounds incommercial applications. Novel techniques for classical resolution,new methodologies for developing selective enzymes forbiocatalysis, advances in the application of microorganisms forchemical production, and continued progress in the area ofasymmetric synthesis have all contributed to the growth of thisfield. Part One of each book contains four chapters which provide anintroduction to topics relevant to the field of chiral chemistryand includes a brief overview of chirality, a short discussion onthe current market drivers in the area of chiral chemistry, and abasic presentation of the various sources and methods for obtainingchiral compounds. Part Two presents entries for over 2500 chiral drugs, classified bytherapeutic class. For each main entry, the chemical name and alist of trade names and synonyms is provided; the CAS RegistryNumber, the European Inventory of Existing Commercial ChemicalSubstances (EINECS) number, and the Merck Index (12th edition)number are given when available. The physical properties, includingspecific rotation, of each compound are described and indicatedapplications are presented. The structure of nearly every compoundis provided, and the manufacturers and suppliers of the compoundsare also given. Indexes, including a master index of names andsynonyms and an index of custom manufacturing services forproduction of chiral compounds, are appended. Chiral Drugs provides an introduction to the types of sources andmethods currently in use for obtaining chiral molecules and is aninvaluable resource for researchers in the pharmaceutical andbiotechnology sectors as well as to those working in the basicbiochemical sciences. Chiral Intermediates provides an introductionto the types of sources and methods currently in use for obtainingchiral molecules and is an invaluable resource for information onavailable chiral molecules. Chiral Intermediates and Chiral Drugsare the most comprehensive and detailed guides to chiral compoundsavailable.
Autorenporträt
Cynthia A Challener currently works as a freelance writer and information management consultant to the chemical industry. She has had experience in research and development, technical support, regulatory compliance, marketing and document and information management. Cynthia received her BS in Chemistry in 1986 from Stanford University and her PhD in Organic Chemistry in 1990 from the University of Chicago.
