Chiral Recognition in Separation Methods

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Mechanisms and Applications

ISBN: 3642124445
ISBN 13: 9783642124440
Herausgeber: Alain Berthod
Verlag: Springer Verlag GmbH
Umfang: xiv, 337 S.
Erscheinungsdatum: 23.06.2010
Auflage: 1/2010
Produktform: Gebunden/Hardback
Einband: GEB

The importance of chiral interactions for both preparative and analytical separations, particularly for pharmaceutical applications, is underlined by numerous publications in this field. Here, for the first time, a team of experienced analysts from industry and academe presents a comprehensive review of the various mechanisms that result in enantiomer separations. A better understanding of these processes is crucial for setting as well as improving chiral separation procedures and also for developing new applications. The coverage in this book includes a range of separation methods, such as gas, liquid, or countercurrent chromatography, and capillary electrophoresis. The special case of chiral ionic liquids is examined in detail. Most modern chiral selectors are discussed, including derivatized polysaccharide- and cyclodextrin-based selectors, along with a newly introduced class of carbohydrates: the cyclofructose selectors. This publication will be required reading not only for research and development departments in the pharmaceutical and cosmetic industries, but also for researchers in toxicology, environmental monitoring, and food research.

Artikelnummer: 1773399 Kategorie:

Beschreibung

What drives a scientist to edit a book on a speci c scienti c subject such as chiral mechanisms in separation methods? Until December 2005, the journal Analytical Chemistry of the American Chemical Society (Washington, DC) had an A-page section that was dedicated to simple and clear presentations of the most recent te- niques or the state of the art in a particular eld or topic. The "A-page" section was prepared for a broad audience of chemists including industrial professionals, s- dents as well as academics looking for information outside their eld of expertise. 1 Daniel W. Armstrong, one of the editors of this journal and a twenty-year+ long friend, invited me to present my view on chiral recognition mechanisms in a simple and clear way in an "A-page" article. In 2006, the "A-page" section was maintained as the rst articles at the beginning of each rst bi-monthly issue but the pagination was no longer page distinguished from the regular research articles published by the journal. During the time between the invitation and the submission, the A-page section was integrated into the rest of the journal and the article appeared as (2006) Anal Chem (78):2093-2099.

Inhaltsverzeichnis

Chiral recognition mechanisms in enantiomers separations: a general view.- Preparation and chiral recognition of polysaccharide-based Selectors.- Description and evaluation of chiral interactive sites on bonded cyclodextrin stationary phases for liquid chromatography.- Cyclofructans, a new class of chiral stationary phases.- Chiral recognition and enantioseparation mechanisms in capillary electrokinetic chromatography.- Chiral recognition mechanism: practical considerations for pharmaceutical analysis of chiral compounds.- Chiral recognition with macrocyclic glycopeptides: mechanisms and applications.- Vancomycin molecular interactions: antibiotic and enantioselective mechanisms.- Enantioselective recognition in solution: the case of countercurrent chromatography.- Enantioselective properties of nucleic acid aptamer. Molecular recognition elements.- Chiral ionic liquids in chromatographic separation and spectroscopic discrimination.

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