Beschreibung
Viruses have developed a variety of different mechanisms to infect and manipulate host cells to their benefit and escape the immune system, as hosts evolve to fight viral infections. This book covers many aspects of current research in molecular virology and addresses the interaction between viruses and their respective host cells. The reader learns how the Karposis sarcoma herpes virus reprograms B-cell metabolism, how coronaviruses affect the eukaryotic cytoskeleton, how influenza viruses interact with host lipids, and the role of transportin-1 for influenza virus entry, to name but a few examples. In addition, this multi-author text covers general biological principles of viral infections and host cell defense strategies. The reader learns how apoptosis and phagocytosis serve as antiviral mechanisms of the host, how physical factors influence the success of viral infections, and the critical importance of interferon-lambda signaling in regulating the innate immune system to fight viruses.In addition, this book covers a number of advanced techniques and methodological breakthroughs for studying virus-infected cells, including cryo-EM, volumetric imaging, single particle tracking, and correlative light and X-ray tomography. With cuttingedge contributions from experts in their respective fields, this book is an informative resource for experienced virologists and early career scientist alike, who want to learn more about the fascinating world of viruses.
Autorenporträt
Dr Swetha Vijayakrishnan is a Research Associate in the MRC-University of Glasgow Centre for Virus Research, within the Structural Virology Group of Professor David Bhella. She has broad experience in structural biology and virology. The Group is currently engaged in research into caliciviruses, influenzaviruses and paramyxoviruses (respiratory syncytial virus, parainfluenza viruses and measles virus). Dr Yaming Jiu is a Principal Investigator at the Institute Pasteur of Shanghai, Chinese Academy of Sciences, Unit of Cell Biology and Imaging Study of Pathogen Host Interaction. She has broad research interests in the fields of cytoskeleton- and intracellular trafficking- centric view of the world at both cellular and behavior level to understand (1) how pathogens target to the cytoskeletal system and membrane trafficking of hosts to regulate their invasion, duplication, and mobility between host cells; (2) the molecular mechanisms of cytoskeletal interaction and the regulation to cell migration, polarity and mechanosensing; (3) related bioimaging methods. Professor Dr J. Robin Harris is an Honorary Professor of the University of Mainz, who specialized in macromolecular electron microscopy. He has been the Series Editor for the Springer Subcellular Biochemistry book series for many years and has personally edited and co-edited several books in this series.
