Beschreibung
PEBPs (PhosphatidylEthanolamine Binding Proteins) form a protein family widely present in the living world. In humans, PEBP1 is also named RKIP (Raf Kinase Inhibitory protein) due to its role as an inhibitor of Raf1. The many studies carried out on human PEBP1 has demonstrated its function as a metastasis suppressor in cancer and also its implication in Alzheimers disease, diabetes and nephropathies. PEBP1 was described to inhibit numerous kinases implicated in various signaling pathways and to be involved in many cellular processes. Among the cellular processes modulated by PEBP1 are signal transduction, inflammation, cell cycle, proliferation, adhesion, differentiation, apoptosis, autophagy, circadian rhythm and mitotic spindle checkpoint. The aim of this review is to highlight the molecular systems that are common to all these cellular mechanisms in order to decipher the specific role of PEBP1. This publication should be useful for researchers, physicians and students concerned by the molecular mechanisms that lead up to major pathologies such as cancer, Alzheimers disease and diabetes.
Autorenporträt
F. Schoentgen and S. Jonic (PhDs), researchers at CNRS, are working in Paris Sorbonne University. A central axis of their search is to study the relationships between structure and function of proteins and molecular complexes. More particularly, Françoise Schoentgen (Research Director) has been studying PEBP1/RKIP for many years.
Herstellerkennzeichnung:
BoD - Books on Demand
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