Beschreibung
All three peroxisome proliferator-activated receptor (PPAR) subtypes share a high degree of structural homology while exhibiting differences in function, tissue distribution, and ligand specificity. In Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances, the authors trace the history of PPAR discovery and detail the receptor structure and its posttranslational modifications. Furthermore, endogenous ligands as well as various classes of exogenous ligands, subtype-selective, dual and pan agonists as well as antagonists, are discussed. In addition, the tissue distribution and versatile functions of PPAR subtypes in major organs are described. As PPARs play critical roles as regulators of numerous physiological as well as pathophysiological pathways, Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances aims to help researchers to develop safer and more effective PPAR modulators as therapeutic agents to treat a myriad of diseases and conditions.
Autorenporträt
InhaltsangabeI. IntroductionII. History of PPAR DiscoveryA. PeroxisomesB. Peroxisomal biogenesis and diseasesC. Peroxisome proliferation III. Peroxisome Proliferator-Activated ReceptorsA. Chromosomal location and gene polymorphismi. PPARaii. PPARb/diii. PPARg B. Protein structurei. N-terminal end (A/B domain)ii. DNA binding domain (DBD, C domain)iii. Hinge region (D domain)iv. Carboxyl terminal end (E/F domain) IV. PPAR LigandsA. Endogenous ligandsB. Exogenous PPAR modulators V. Tissue Distribution and Versatile Functions of PPARsA. Neurological functions of PPARsB. PPARs and the cardiovascular systemC. PPARs in pulmonary physiology and diseaseD. Gastrointestinal roles of PPARsE. PPAR functions in the liverF. Roles of PPARs in the pancreasG. PPARs in the urinary tract physiology and pathophysiologyH. PPARs in the reproductive systemI. Bone metabolism and PPARsJ. Roles of PPARs in skeletal muscle biologyK. Skin PPARs VI. PPARs and Drug Metabolism VII. Molecular Aspects of PPAR ActionsA. Posttranslational control of PPARsB. Mechanism of action VIII. Animal Models in PPAR Research IX. Safety of PPAR Agonists X. The Future of PPAR Research XI. References
