Beschreibung
Prions are a new concept in medicine and biology. The concepts about -helix, -sheet, peptide bond, hydrogen bonds are discussed. Prion diseases cause fatal zoonotic transmissible spongiform encephalopathy, Alzheimer, Huntington and Parkinson diseases in animals and humans. The earliest known Prion disease is Scrapie. Kuru is a fatal neurodegenerative disorder caused by abnormally folded Prion proteins, which leads to symptoms as tremors, loss of coordination. Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker syndrome are fatal degenerative brain disorders. Fatal familial insomnia results in trouble sleeping. Alzheimer disease causes 60-70% of dementia. Huntington disease is inherited results in the death of brain cells. Prion disease is the transition from -helix-rich PrPC to rich in -sheets, responsible for aggregates, and amyloid fibrils. There is no therapeutics to reverse human Prion diseases. Heparin mimetics inhibits Prion propagation in Scrapie infected cells. Other antiprion drugs are tetrapyrroles, branched polyamines, lichens, and -sheet breaker peptides.
Autorenporträt
Jose A. O'Daly Carbonell. American Citizen. Country of birth: Caracas, Venezuela. Secondary School: La Salle High School, Caracas. University: Central University of Venezuela, Caracas. MD, 1958-1964. DMSc, 1965-1968. Johns Hopkins University, PhD. 1967-1971. Publications International Journals:79, Journals for Scientific Publications:17
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