Beschreibung
Inhaltsverzeichnis
Immunotoxicity Testing: Methods and Protocols Editor Rodney R. Dietert Table of Contents: Table of Contents Preface Contributors Part I - Introduction Immunotoxicology Testing: Past and Future Michael I. Luster and G. Frank Gerberick Part II - Overview and Health-Risk Considerations Developmental Immunotoxicity (DIT): The Why, When and How of DIT Testing. Rodney R. Dietert and Jamie DeWitt An In Vivo Approach to Test Immunosensitization by Low Moelcular Weight Compounds Irene S. Ludwig, Lydia M. Kwast, Danielle Fiechter, Raymond H.H. Pieters Risk of Autoimmune Disease: Challenges for Immunotoxicity Testing Rodney R. Dietert, Janice M. Dietert and Jerrie Gavalchin Markers of Inflammation Dori R. Germolec, Rachel P. Frawley, and Ellen Evans Evaluating Macrophages in Immunotoxicity Testing John B. Barnett and Kathleen M. Brundage Part III - Immunotoxicity and Host Resistance Models Host Resistance Assays Including Bacterial Challenge Florence G. Burleson and Gary R. Burleson Viral Host Resistance Studies Wendy Jo Freebern Parasite Challenge as Host Resistance Models for Immunotoxicity Testing Robert W. Luebke Tumor Challenges in Immunotoxicity Testing Sheung Ng, Kotaro Yoshida, and Judith T. Zelikoff Part IV - Testing Protocols in Rodents and Other Laboratory Animals The T-dependent Antibody Response to Keyhole Limpet Hemocyanin in Rodents Lisa M. Plitnick and Danuta J. Herzyk The T-Dependent Antibody Response to Sheep Erythrocytes Kimber L. White, Jr., Deborah L. Musgrove, and Ronnetta D. Brown 13. The Delayed Hypersensitivity (DTH) Assay Using Protein and Xenogeneic CellAntigens Rodney R. Dietert, Terry L. Bunn and Ji-Eun Lee 14. The Cytotoxic T Lymphocyte (CTL) Assay For Evaluating Cell-Mediated Immune Function Gary R. Burleson, Florence G. Burleson and Rodney R. Dietert 15. NK Cell Assays in Immunotoxicity Testing Qing Li 16. The Local Lymph Node Assay and Skin Sensitization Test Ian Kimber and Rebecca J. Dearman 17. Use of Contact Hypersensitivity in Immunotoxicity Testing Jacques Descotes 18. Evaluation of Apoptosis in Immunotoxicity Testing Sadiye Amcaoglu Rieder, Dilip Vakharia, Prakash S. Nagarkatti and MitziNagarkatti 19. Dendritic Cells in Immunotoxicity Testing Donghong Gao and David A. Lawrence 20. Evaluating Cytokines in Immunotoxicity Testing Emanuela Corsini and Robert V. House 21. Flow Cytometry in Preclinical Drug Development Patrick B. Lappin 22. Expanded Histopathology of Lymphoid Organs Susan A. Elmore 23. Immunotoxicity Testing in Nonhuman Primates Stephanie Grote-Wessels, Werner Frings, Clifford A. Smith, Gerhard F. Weinbauer Part V - Evaluation in Humans 24. Fundamentals of Clinical Immunotoxicology Robert V. House Part VI - Wildlife Testing 25. In Vivo Functional Tests for Assessing Immunotoxicity in Birds Keith A. Grasman Part VII - In Vitro Alternatives 26. In Vitro Testing for Direct Immunotoxicity: State-of-the-Art D. P. K. Lankveld, Henk van Loveren, K. A. Baken and R. J. Vandebriel
