Beschreibung
The objective of the present work was to develop and optimize Azilsartan loaded polymeric nanoparticles using factorial design. The factorial design was used for studying the effect of the main preparation variables on particle size, polydispersity index, entrapment efficiency and percentage of cumulative drug release after 12 hours of the nanoparticles. A modified emulsification method was used to prepare nanoparticles successfully by using the biodegradable polymer poly(L-lactide) (PLA), and they were characterized for various parameters. The characterized parameters of nanoparticles produced include their particle size, polydispersity index, entrapment efficiency and percentage of cumulative drug release after 12 hours. Morphology of nanoparticles was studied with scanning electron microscope (SEM). Examination of the interaction between the excipients used as well as investigation of the nature of the drug and the formulation was carried out by FTIR studies.
Autorenporträt
Tai Yee Ling is student of Bachelor of Pharmacy (HONS) in Asian Institute of Medicine Science and Technology (AIMST) University, Kedah, Malaysia. She performed formulation and optimization of Azilsartan nanoparticles. She expressed her sincere gratitude to her parents, lecturers, family and friends for their guidance throughout the project.
Herstellerkennzeichnung:
BoD - Books on Demand
In de Tarpen 42
22848 Norderstedt
DE
E-Mail: info@bod.de
