Beschreibung
Since the first edition there has been a great demand for this book. It has been revised to include up-to-date and new entries covering recent additions to the availa ble drugs. As well there are now sections on clinical situations, or types of patient, presenting especial problems. The authors hope this new material will enhance the effectiveness of the book as a guide to this rapidly advancing and changing therapeutic situation. A.P.B. J.A.G. J.McC.M. July, 1978 v Contents I. Antibacterial Drugs 1.1 Mechanisms of Action I.2 Side Effects and Toxicity 2 2. The Sulphonamides. 2 2.1 Antibacterial Activity. 2 2.2 Mode of Antibacterial Action 2.3 Pharmacology 3 2.4 Therapeutic Indications. 4 2.5 Dosage. 4 2.5.1 Short Acting Sulphonamides. 4 2.5.2 Long Acting Sulphonamides 5 2.5.3 Non-absorbable Sulphonamides 5 2.6 Side Effects and Toxicity 5 2.6.1 Nephrotoxicity. 5 2.6.2 Haematological Abnormalities 5 2.6.3 Pulmonary Disease. 5 2.6.4 Hypersensitivity. 6 2.7 Drug Interactions. 6 3. The Natural Penicillins - Benzylpenicillin (Penicillin G) and Phenoxymetbylpe- cillin (Penicillin V).
Autorenporträt
Inhaltsangabe1. Antibacterial Drugs.- 1.1 Mechanisms of Action.- 1.2 Side Effects and Toxicity.- 2. The Sulphonamides.- 2.1 Antibacterial Activity.- 2.2 Mode of Antibacterial Action.- 2.3 Pharmacology.- 2.4 Therapeutic Indications.- 2.5 Dosage.- 2.5.1 Short Acting Sulphonamides.- 2.5.2 Long Acting Sulphonamides.- 2.5.3 Non-absorbable Sulphonamides.- 2.6 Side Effects and Toxicity.- 2.6.1 Nephrotoxicity.- 2.6.2 Haematological Abnormalities.- 2.6.3 Pulmonary Disease.- 2.6.4 Hypersensitivity.- 2.7 Drug Interactions.- 3. The Natural Penicillins - Benzylpenicillin (Penicillin G) and Phenoxymethylpenicillin (Penicillin V).- 3.1 Physicochemical Properties.- 3.2 Mode of Antibacterial Action.- 3.3 Antibacterial Activity.- 3.3.1 Activity Against Streptococci.- 3.3.2 Activity Against Staphylococci.- 3.3.3 Activity Against Other Organisms.- 3.4 Pharmacology.- 3.4.1 Penicillin G.- 3.4.2 Benzathine and Procaine Salts of Penicillin G.- 3.4.3 Penicillin V.- 3.5 Therapeutic Indications.- 3.5.1 Streptococcal Infections.- 3.5.2 Meningococcal Infections.- 3.5.3 Gonorrhoea.- 3.5.4 Other Infections.- 3.6 Dosage.- 3.6.1 Penicillin G.- 3.6.2 Procaine and Benzathine Penicillin.- 3.6.3 Penicillin V.- 3.7 Side Effects and Toxicity.- 3.7.1 Neurotoxicity.- 3.7.2 Nephritis.- 3.7.3 Haemolysis.- 3.7.4 Hypersensitivity.- 3.7.5 Side Effects of Penicillin V.- 4. The Semi-synthetic Penicillins.- 4.1 Phenoxypenicillins.- 4.2 Penicillinase Resistant Penicillins.- 4.2.1 Methicillin.- 4.2.2 Isoxazolyl Penicillins.- 4.3 Other Penicillinase Resistant Penicillins.- 4.4 Broad Spectrum Penicillins.- 4.4.1 Ampicillin.- 4.4.2 Amoxycillin.- 4.4.3 Epicillin.- 4.4.4 Hetacillin, Pivampicillin and Talampicillin.- 4.4.5 Carbenicillin.- 4.4.6 Carindacillin (Indanyl Carbenicillin).- 5. Mecillinam and Pivmecillinam.- 5.1 Antibacterial Activity.- 5.2 Mode of Action.- 5.3 Pharmacology.- 5.4 Indications.- 5.5. Dosage.- 5.6 Side Effects.- 6. Co-trimoxazole (Trimethoprim-sulphamethoxazole).- 6.1 Antibacterial Activity.- 6.1.1 Gram-positive Bacteria.- 6.1.2 Gram-negative Bacteria.- 6.1.3 Miscellaneous.- 6.2 Mode of Action.- 6.3 Pharmacology.- 6.4 Indications.- 6.4.1 Urinary Tract Infections.- 6.4.2 Bacteraemic Syndromes.- 6.4.3 Gonorrhoea.- 6.4.4 Chest Infections.- 6.4.5 Enteric Fever.- 6.4.6 Brucellosis.- 6.4.7 Miscellaneous.- 6.5 Dosage.- 6.6 Contraindications.- 6.7 Side Effects and Toxicity.- 6.7.1 Haematological Abnormalities.- 6.7.2 Hypersensitivity.- 6.7.3 Nephrotoxicity.- 6.8 Drug Interactions.- 7. Chloramphenicol.- 7.1 Therapeutic Indications.- 7.1.1 Enteric Fever.- 7.1.2 Other Indications.- 8. The Tetracyclines.- 8.1 Antibacterial Activity.- 8.1.1 Spectrum of Activity.- 8.1.2 Development of Resistance.- 8.2 Pharmacology.- 8.3 Therapeutic Indications.- 8.4 Side Effects and Toxicity.- 8.4.1 Tooth Discoloration.- 8.4.2 Renal Toxicity.- 8.4.3 Liver Toxicity.- 9. The Macrolides.- 9.1 Erythromycin.- 9.1.1 Physicochemical Properties.- 9.1.2 Antibacterial Activity.- 9.1.3 Pharmacology.- 9.1.4 Therapeutic Indications.- 9.1.5 Dosage.- 9.1.6 Side Effects and Toxicity.- 9.2 Spiramycin and Triacetyloleandomycin.- 10. Lincomycin and Clindamycin.- 10.1 Mode of Action.- 10.2 Antibacterial Activity.- 10.3 Pharmacology.- 10.4 Therapeutic Indications.- 10.5 Dosage.- 10.6 Side Effects and Toxicity.- 11. Fusidic Acid (Sodium Fusidate).- 11.1 Mode of Action.- 11.2 Antibacterial Activity.- 11.3 Pharmacology.- 11.4 Therapeutic Indications.- 11.5 Dosage.- 11.6 Side Effects and Toxicity.- 12. The Urinary Antiseptics.- 12.1 Nitrofurantoin.- 12.1.1 Physicochemical Properties.- 12.1.2 Antibacterial Activity.- 12.1.3 Pharmacology.- 12.1.4 Therapeutic Indications.- 12.1.5 Dosage.- 12.1.6 Side Effects and Toxicity.- 12.2 Nalidixic Acid.- 12.2.1 Antibacterial Activity.- 12.2.2 Pharmacology.- 12.2.3 Therapeutic Indications and Dosage.- 12.2.4 Side Effects and Toxicity.- 12.3 Oxolinic Acid.- 13. Cephalosporins.- 13.1 Cephaloridine.- 13.1.1 Antibacterial Activity.- 13.1.2 Pharmacology.- 13.1.3 Indications.- 13.1.4 Dosage.- 13.1
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