Tumor Suppressor Par-4
Lieferzeit: Lieferbar innerhalb 14 Tagen
181,89 €
Structural Features, Molecular Mechanisms and Function
| ISBN: |
3030735710 |
| ISBN 13: |
9783030735715 |
| Herausgeber: |
Vivek M Rangnekar |
| Verlag: |
Springer Verlag GmbH |
| Umfang: |
x, 323 S., 3 s/w Illustr., 81 farbige Illustr., 323 p. 84 illus., 81 illus. in color. |
| Erscheinungsdatum: |
09.01.2022 |
| Auflage: |
1/2022 |
| Produktform: |
Gebunden/Hardback |
| Einband: |
Gebunden |
Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar’s laboratory in prostate cancer cells undergoing apoptosis. Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule’s structural features, key functional domains, regulation and relevant basic and clinical/translational facets.
