Beschreibung
This exhaustive work shows that new therapies using anti-angiogenic drugs are of particular importance because they can be used against many different types of cancer, as tumor angiogenesis seems to be involved in most if not all solid metastasizing malignancies. The first part of this book summarizes the knowledge acquired on the molecular entities that play a role in tumor angiogenesis and their mechanisms of action. Furthermore, the identification of molecular markers and their validation as predictive and/or prognostic tools is reviewed. In the second and most important part, the clinical applications of anti-angiogenic treatments are documented for a wide variety of tumors. In particular, the modes of combination with other targeted and/or cytotoxic cancer therapies are presented.
Autorenporträt
Dieter Marmé is renowned for his scientific work on molecular biology and tumor biology. At the time of his retirement in 2005 he had spent more than a decade at the Tumor Biology Center in Freiburg, Germany (an institution privately organized and academically linked to the University of Freiburg). He initially joined the Center as Director of the Institute of Molecular Medicine upon its foundation in 1993 and later served as its Director of Research and Chairman of the Board of Directors. After graduating with a Diploma in Physics and Mathematics and gaining a PhD in Biology from the University of Freiburg, Dr. Marmé joined the Department of Genetics and Molecular Biology at the Faculty of Biology, University of Freiburg. He subsequently undertook a research assistantship at Harvard University, where he worked in the laboratory of Prof. Winslow Briggs. After returning to the University of Freiburg, he obtained his Habilitation in 1974 and in 1982 was appointed as an Extraordinary Professor in the Department of Genetics and Molecular Biology. In 1983 Dr. Marmé became Head of Pharmacological Biochemistry at Gödecke, a division of Parke-Davis (now Pfizer), and was later promoted to become Head of Biological Research. At that time he was also leading a consortium of researchers and clinicians from the University and the University Medical School in Freiburg as well as from the Max Planck Institute of Immunology in Freiburg to investigate the molecular mechanisms of cancer. Following his move to the Tumor Biology Center, he started a drug development program together with Ciba-Geigy (now Novartis) as a privatepublic partnership program. Upon retiring from the Tumor Biology Center in 2005, he continued to work for the institution as an Adviser in Oncology and at the same time became a member of the editorial board for various journals in the field of oncology and a consultant for pharmaceutical companies. Since 1989 Dr. Marmé's research has focused on the roles of growth factors in the mechanisms by which tumor angiogenesis is initiated and propagated, with particular attention to VEGF-dependent angiogenic processes. He is co-editor of the previous Springer book Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy (2008).
Herstellerkennzeichnung:
Springer Verlag GmbH
Tiergartenstr. 17
69121 Heidelberg
DE
E-Mail: juergen.hartmann@springer.com
