Small-Molecule Inhibitors of Protein-Protein Interactions

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Current Topics in Microbiology and Immunology 348

ISBN: 3642266703
ISBN 13: 9783642266706
Herausgeber: Lyubomir Vassilev/David Fry
Verlag: Springer Verlag GmbH
Umfang: x, 174 S.
Erscheinungsdatum: 27.02.2013
Auflage: 1/2013
Produktform: Kartoniert
Einband: KT

body>In this volume, the editors have collected the knowledgeable insights of a number of leaders in this field – researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions. These researchers describe their unique approaches, and share experiences, results, thoughts, and opinions. The content of the articles is rich, and in terms of scope ranges from generalized approaches to specific case studies. There are various focal points, including methodologies and the molecules themselves. Ultimately, there are numerous lessons to be taken away from this collection, and the editors hope that this snapshot of the current state of the art in developing protein-protein inhibitors not only pays tribute to the past successes, but also generates excitement about the future potential of this field.

Artikelnummer: 4428205 Kategorie:

Beschreibung

InhaltsangabePreface.- Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions.- Small-molecule inhibitors of IL-2/IL-2R: lessons learned and applied.- Small molecule inhibitors of the human papillomavirus E1-E2 interaction.- Design of small-molecule Smac mimetics as IAP antagonists.- Small-molecule inhibitors reveal a new function for Bcl-2 as a pro-angiogenic signaling molecule.- Small-molecule modulators of c-Myc/Max and Max/Max interactions.-  Small-molecule inhibitors of the p53-MDM2 interaction.- Subject index

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