Beschreibung
The vast growth of knowledge in recent years concerning the functional role of serotonergic systems in central nervous system function prompted the organization of the symposium. The organiz ing committees felt at the onset that the field of serotonin research had grown so rapidly that it would be impossible to cover every aspect of it in individual symposia. Thus it was felt that certain areas of research had to be omitted due to time constraints, and we extend an apology to the researchers in areas not included in these proceedings. Rather it was hoped to provide a balance overview of the field, starting with the anatomy of serotonergic systems and proceeding to the level of the serotonergic receptors at the cell membrane, and then inside the neuron to discuss the regulation of serotonin bisynthesis and integration within indole mine systems. The functional aspects of serotonergic transmission focused on the emerging role of this amine in the processing of nociceptive information, singly or in tandem with other neurotran smitters or neuromodulators. A separate symposium dealt with a variety of animal models suitable for the analysis of the role of serotonin in behavior, and finally led to the evaluation of serotonin metabolism in the study of abnormal human behavior. The editors would like to dedicate these proceedings on /Serotonin - Current Aspects of Neurochemistry and Function/ to two pioneers in this field, Dr. Irving Page and Dr. Maurice Rapport.
Autorenporträt
InhaltsangabeSection I Neuroanatomy of Serotonergic and Related Systems.- Localization of Serotonin-Like Immunoreactivity in the Central Nervous System and Pituitary of the Rat, with Special References to the Innervation of the Hypothalamus.- Serotonin Binding Protein: Role in Transmitter Storage in Central and Peripheral Serotoneroic Neurons.- Radioautographic Investigation of Serotonin Cells.- Anatomical Evidence for GABA-5 HT Interaction in Serotonergic Neurons.- Evidence for the Coexistence of Serotonin and Substance P in Single Raphe Cells and Fiber Plexuses: Combined Immunocytochemistry and Autoradiography.- Section II Role of Serotonin in Processing of Nociceptive Information.- Effects of Peripherally and Centrally Administered Serotonin on Primate Spinothalamic Neurons.- The Role of Serotonin in Modulation of Nociceptive-Reflexes.- Role of the Raphe Nuclei in Stimulation Producing Analgesia.- Descending Control of Pain Transmission: Possible Serotonergic-Enkephalinerginc Interactions.- Section III The Regulation of Synthesis.- Synthesis and Quantitative Aspects of Dihydrobiopterin Control of Cerebral Serotonin Levels.- Influence of Plasma Trytophan on Brain 5-HT Synthesis and Serotonergic Activity.- Tryptophan Availability and the Control of 5-Hydroxytryptamine and Tryptamine Synthesis in Human CNS.- Regulatory Properties of Neuronal Tryptophan Hydroxylase.- Studies of the Oxygen Sensitivity of Tryptophan Hydroxylase.- Influence of Histamine on Serotonin Metabolism in Rat Brain.- Serotonin and Dopamine Synthesis in Phenylketonuria.- Section IV Serotonin Receptors.- Effect of Serotonin and Melatonin on the Electrophysiological Behaviour of the Plasma Membrane.- Identification of Serotonin-Binding Proteins Using a Photoaffinity Labeling Probe.- Serotonin-Receptors Coupled with an Adenylate Cyclase in the Rat Brain: Non-Identity with 3H-5-HT Binding Sites.- Brain Serotonin Receptors and Neuropsychiatrie Disorders.- Structure-Activity Relationships in the Actions of 1-Phenyl-Piperazines on Brain Serotonin Receptors.- Section V Regulation and Integration of Serotonergic Systems.- The Action of Serotonin in the Rat Hippocampus.- Uptake and Metabolism of Serotonin and Amino Acids in Thiamine Deficiency.- The Serotonin Connection: Some Evidence for a Specific Metabolic Organization.- Role of Serotonin in the Hypothalamic Regulation of Pituitary Function.- Evidence for Neuronal Feedback Regulation of Serotonin Formation in Brain.- Section VI Developmental Aspects of Serotonergic Systems.- Neurohumor Substances as Neural Growth Factors.- Roles for Serotonin in Neuroembryogenesis.- Developmental-Regulatory Aspects of Brain Tryptophan Hydroxylase.- Serotonin in Development of Cyclic Reproductive Function.- Section VII Serotonin and Behavior-Animal Models.- The Interaction of Indole Derivatives with the Serotonin Receptor and Non-Dopaminergic Cicrling Behavior.- Some Behavioural Interactions between 5-Hydroxytryptamine and Dopamine.- Serotonergic-Dopaminergic Interactions: Implications for Hyperkinetic Disorders.- Serotonin Metabolism of Animal Model of Depression.- Hypersensitive Serotonergic Receptors: A New Hypothesis for one Subgroup of Unipolar Depression Derived from an Animal Model.- An Animal Behavior Model for Decreased Central Serotonergic Function.- Studies on the Role of Central 5-HT Neurons in Avoidance Learning: A Behavioral and Biochemical Analysis.- Section VIII Serotonin and Behavior Psychiatry.- On the Clinical Significance of Serotonin and 5-HIAA in Body Fluids.- Serotonin Metabolite Concentrations in Cerebrospinal Fluid from Schizophrenic Patients - Relationships to Family History.- Tryptophan in the Treatment of Depression.- Studies of CSF 5-HIAA in Depression and Suicidal Behaviour.- Serotonin and Dopamine Disturbances in Patients with Unipolar Depression and Parkinsonism.- Abstracts.- ccelerated Turn-Over of Spinal 5-HT by Electrical Stimulation of the Posterior Raphe Nuclei in the Rat.- Actions of Benzodiazepine Drugs on
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