Sepsis

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Methods and Protocols, Methods in Molecular Biology 2321

ISBN: 1071614908
ISBN 13: 9781071614907
Herausgeber: Wendy E Walker
Verlag: Springer Verlag GmbH
Umfang: xiii, 262 S., 3 s/w Illustr., 50 farbige Illustr., 262 p. 53 illus., 50 illus. in color.
Erscheinungsdatum: 30.05.2022
Auflage: 1/2021
Produktform: Kartoniert
Einband: KT

This detailed volume presents a variety of animal models that are commonly used to study sepsis and some key procedures to measure specific disease outcomes. The chapters describe well-established surgical and nonsurgical rodent models of sepsis, presented by experts in the field. In addition, the book includes protocols for burn injury and sepsis, modeling the mouse intensive care unit (MICU), and the development of humanized mice, which may be useful tools to increase the translational potential of rodent sepsis research. There is a chapter discussing the use of biomarkers for sepsis diagnosis and prognosis in humans and mice, as well as chapters describing specific methods for biomarker measurement, and the use of analgesics and humane endpoints in rodent sepsis research. Finally, agent-based computational modeling is presented as a valuable complementary approach to study sepsis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Sepsis: Methods and Protocols serves as an ideal guide for researchers working toward improving the identification and treatment of septic patients.

Artikelnummer: 5665333 Kategorie:

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