Beschreibung
InhaltsangabeThe Key Features of RNA Silencing.- Selected Strategies for the Delivery of siRNA In Vitro and In Vivo.- RNAi Suppression and Its Application.- Strategies to Prevent siRNA-Triggered Cellular Toxicity.- RNAi in Malignant Brain Tumors: Relevance to Molecular and Translational Research.- Silencing Huntington's Disease Gene with RNAi.- Application of Dicer-Substrate siRNA in Pain Research.- RNAi Treatment of HIV-1 Infection.- Application of RNA Interference to Treat Conditions Associated with Dysregulation of Transient Receptor Potential Vanilloid 1 Channel.- Harnessing RNAi-Based Functional Genomics to Unravel the Molecular Complexity Underlying Skin Pigment Variation.- mRNA Structure and its Effects on Posttranscriptional Gene Silencing.- Antisense RNA-Mediated Regulation of the p53 Tumor Suppressor.- Antisense Oligonucleotides: Insights from Preclinical Studies and Clinical Trials.- What can the New Hammerhead Ribozyme Structures Teach us About Design?.- microRNA Biogenesis and its Impact on RNA Interference.- MicroRNAs in Epithelial Antimicrobial Immunity.- Emerging Roles of Long Noncoding RNAs in Gene Expression and Intracellular Organization.- Noncoding RNAs as Therapeutic Targets.- Noncoding RNAs at H19/IGF2 Locus: Role in Imprinting, Gene Expression, and Associated Pathologies.
Inhaltsverzeichnis
Preface.- The key features of RNA silencing. Selected strategies for the delivery of siRNA in vitro and in vivo. RNAi suppression and its application. Strategies to prevent siRNA-triggered cellular toxicity. RNAi in malignant brain tumors: relevance to molecular and translational research. Silencing Huntington''s disease (HD) gene with RNAi. Application of Dicer-substrate siRNA in pain research. RNAi treatment of HIV-1 infection. Application of RNA Interference to Treat Conditions Associated with Dysregulation of TRPV1. Harnessing RNAi-based Functional Genomics to Unravel the Molecular Complexity Underlying Skin Pigment Variation. mRNA structure and its effects on post-transcriptional gene silencing. Antisense RNA-mediated regulation of the p53 tumor suppressor. Antisense oligonucleotides: insights from preclinical studies and clinical trials. What can the new hammerhead ribozyme structures teach us about design? microRNA biogenesis and its impact on RNA interference. MiroRNAs in Epithelial Anti-microbial Immunity. Emerging roles of long noncoding RNAs in gene expression and intracellular organization. Noncoding RNAs as therapeutic targets. Non coding RNAs at H19/IGF2 locus: Role in imprinting, gene expression and associated pathologies.