Beschreibung
InhaltsangabePreface.- Introduction.- Expression of N-Acetylaspartate and N-Acetylaspartate metabolism in Neural Cells.- NAA Synthesis and Functional Roles.- Identity of the High-Affinity Sodium/Carboxylate Cotransporter NAC3 as the NAA Transporter.- The Knockout Mouse for Canavan Disease and the Human Counterpart.- Function of NAA and NAAG in Brain.- Control of Brain Volume During Hypoosmolar and Hyperosmolar Conditions.- Physiological Role of N-Acetylaspartate.- Defective Myelin Lipid Synthesis as a Pathogenic Mechanism in Canavan Disease.- Mutation Analysis of the Aspartoacylase Gene in Non-Jewish Patients with Canavan Disease.- Does ASPA Gene Mutation in Canavan Disease Alter Oligodendrocyte Development?.- Quantitation of NAA in the Brain by Magnetic Resonance Spectroscopy.- N-Acetyl-l-Aspartate in Multiple Sclerosis.- NAA and Highger Cognitive Function in Humans.- In Vivo NMR Measures of NAA and the Neurobiology of Schizophrenia.- N-Acetyl Aspartate as a Marker of Neuronal Injury in Neurodegenerative Disease.- Regulation of NAA-Synthesis in the Human Brain In Vivo. Canavan's Disease, Alzheimer's Disease and Schizophrenia.- Magnetic Resonance Spectroscopy for Monitoring Neuronal Integrity in Amyotrophic Lateral Sclerosis.- Hypo-Acetylaspartia: Clinical and Biochemical Follow-up of a Patient.- Cellular Localization of NAAG.- Synthesis of N-Acetylaspartylglutamate (NAAG) and N-Acetylaspartate (NAA) in Axons and Glia of the Crayfish Medial Giant Nerve Fiber.- NAAG as Neurotransmitter.- Glutamate Carboxypeptidase II (NAALADase) Inhibition as a novel Therapeutic Strategy.- N-Acetylaspartylglutamate (NAAG) in Spinal Cord Injury and Disease.- N-Acetylaspartylglutamate (NAAG) in Pelizaeus-Merzbacher Disease.- Concluding Remarks.
Autorenporträt
InhaltsangabeA Brief Overview of N-Acetylaspartate and N-Acetylaspartylglutamate.- Expression of N-Acetylaspartate and N-Acetylaspartylglutamate in the Nervous System.- N-Acetylaspartate Metabolism in Neural Cells.- Naa Synthesis and Functional Roles.- Identity of the High-Affinity Sodium/Carboxylate Cotransporter NaC3 as the N-Acetyl-L-Aspartate Transporter.- Canavan Disease: Studies on the Knockout Mouse.- Functions Of N-Acetylaspartate and N-Acetylaspartylglutamate in Brain.- Control of Brain Volume during Hypoosmolality and Hyperosmolality.- Physiological Role of N-Acetylaspartate.- Defective Myelin Lipid Synthesis as a Pathogenic Mechanism of Canavan Disease.- Mutation Analysis of the Aspartoacylase Gene in Non-Jewish Patients with Canavan Disease.- Does ASPA Gene Mutation in Canavan Disease Alter Oligodendrocyte Development?.- Quantitation of NAA in the Brain by Magnetic Resonance Spectroscopy.- N-Acetyl-L-Aspartate in Multiple Sclerosis.- NAA and Higher Cognitive Function in Humans.- In Vivo NMR Measures of NAA and the Neurobiology of Schizophrenia.- N-Acetylaspartate as a Marker of Neuronal Injury in Neurodegenerative Disease.- Regulation of NAA-Synthesis in the Human Brain in Vivo: Canavan's Disease, Alzheimer's Disease and Schizophrenia.- Magnetic Resonance Spectroscopy for Monitoring Neuronal Integrity in Amyotrophic Lateral Sclerosis.- Hypoacetylaspartia: Clinical and Biochemical Follow-Up of a Patient.- Cellular Localization of NAAG.- Synthesis of N-Acetylaspartylglutamate (NAAG) and N-Acetylaspartate (NAA) in Axons and Glia of the Crayfish Medial Giant Nerve Fiber.- NAAG as a Neurotransmitter.- Glutamate Carboxypeptidase II (NAALADase) Inhibition as a Novel Therapeutic Strategy.- N-Acetylaspartylglutamate (NAAG) in Spinal Cord Injury and Disease.- N-Acetylaspartylglutamate (NAAG) in Pelizaeusmerzbacher Disease.- Concluding Remarks.
