Beschreibung
Lymphoma and leukemia of the nervous system may be defined as direct or indirect involvement of the central or peripheral nervous systems by these malignancies. The diagnosis and management of these conditions is the subject of this book. In the first part of the book the focus is on primary central nervous system lymphoma (PCNSL), an uncommon type of non-Hodgkin lymphoma confined to the nervous system. The first two chapters of the book are an overview of the lymphoid malignancies and leukemias for non-oncologists. This introduction is followed by chapters on the pathology, epidemiology, diagnosis and management of PCNSL. These chapters review PCNSL in immunocompetent hosts as well as in the setting of immunosuppression. The management of patients with PCNSL involves treatment regimens that are different than the typical approaches used in patients with primary brain tumors or with systemic forms of non-Hodgkin lymphoma. The optimal treatment for patients with PCNSL has yet to be defined and several fundamental therapeutic questions, including the optimal role of radiation and other consolidation therapies, are unresolved. In the final chapters of this section a number of special topics including ocular lymphoma, neurolymphomatosis and intravascular lymphoma of the nervous system are reviewed. In the second part of the book the neurological complications of the lymphoid malignancies and leukemias are reviewed. The neurotoxicity of therapies for lymphoma and leukemia are also covered in this section of the book. Brain, epidural and leptomeningeal metastases are examples of direct involvement of the nervous system while paraneoplastic complications are an example of indirect involvement of the nervous system. Although exceptions exist the prognosis is usually poor once lymphoma or leukemia involves the nervous system. Prevention of neurological complications with better systemic therapy and, possibly, prophylactic intrathecal chemotherapy are areas of active investigation. The diagnosis and management of patients with lymphoma and leukemia of the nervous system involves an interdisciplinary team of hematologists, oncologists, radiation oncologists, neurologists, neurosurgeons and pathologists. A single source of information regarding this group of diseases and complications will hopefully serve as a useful resource for these physicians.
Inhaltsverzeichnis
Foreword - James O. Armitage, Franco Cavalli Preface Part I - Introduction Chapter 1- Overview of the Lymphomas - Jill Lacy, Julie Vose Chapter 2- Overview of the Leukemias - Harshabad Singh, Eyal Attar Part II -Central Nervous System Lymphomas Chapter 3- Pathological features of CNS lymphomas - Judith Ferry, Rolf Pfannl, Nancy Harris Primary CNS lymphoma Chapter 4- Epidemiology - Brian O¿Neill, Ingfrid Haldorsen Chapter 5- Biology - James Rubenstein Chapter 6- Diagnostic Considerations - Tracy Batchelor, Daphne Wang, Edward Neuwelt, Gilbert Gonzalez Chapter 7- Radiation and Combined Modality Therapy - Lisa DeAngelis, Joachim Yahalom Chapter 8- Chemotherapy - Tracy Batchelor, Andrew Grigg, Eckhard Thiel Chapter 9- High-dose chemotherapy - Gerald Illerhaus, Carole Soussain, Patrick Johnston Variants of CNS lymphoma Chapter 10- CNS Lymphoma in the immunocompromised host - Silvia Montoto, Andrew Lister Chapter 11- CNS Post-Transplant Lymphoproliferative Disorder - David Schiff, Samar Issa Chapter 12- Ocular Lymphoma - Andres Ferreri, Jose Pulido Chapter 13- Neurolymphomatosis - Tali Siegal, Joachim Baehring Chapter 14- Intravascular Lymphoma of the CNS - Emanuele Zucca, Jon Glass, Maurilio Ponzoni Chapter 15- Rare variants of PCNSL (T-cell, low-grade, pediatrics) - Kristoph Jahnke, Oussama Abla, Tamara Shenkier Part III - Neurological Complications of Lymphomas and Leukemias Chapter 16- Neurological complications of non-Hodgkin lymphoma - Antonio Omuro, Mark Gilbert Chapter 17- Neurological complications of Hodgkin lymphoma - Elizabeth Gerstner, Maciej Mrugala Chapter 18- Neurological complications of Plasma Cell Disorders - Jan Drappatz, Kurt Jaeckle Chapter 19- Neurological complications of acute and chronic leukemias - Marc Chamberlain Chapter 20- Paraneoplastic syndromes in hematological malignancies - Josep Dalmau Part IV - Neurological Complications of Therapy for Lymphomas and Leukemias Chapter 21- Neurological complications of radiation in lymphoma and leukemia patients -Denise Correa, Lisa DeAngelis Chapter 22- Neurological complications of chemotherapy in lymphoma and leukemia patients - Patrick Wen Chapter 23- Neurological complications of bone marrow transplantation in lymphoma and leukemia patients - Warren Mason, Jacoline Bromberg
Autorenporträt
Lymphomas and leukemias of the nervous system result in devastating neurological complications and high mortality. These malignancies may arise within the central nervous system or may disseminate to the brain or cerebrospinal fluid from a source elsewhere in the body. Early diagnosis and therapeutic intervention lead to improvement in neurological symptoms and signs and potentially improved survival. The diagnostic evaluation and treatment of lymphoma and leukemia of the nervous system differ from the standard approaches used when the disease is confined outside of the nervous system. Lymphoma and Leukemia of the Nervous System is a comprehensive review of this challenging group of diseases and should be useful for the practicing neurologist, hematologist, oncologist and for any practitioner involved in the management of these patients.
