Produktbild: IgM and Its Receptors and Binding Proteins

IgM and Its Receptors and Binding Proteins

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Current Topics in Microbiology and Immunology 408

ISBN: 3319878107
ISBN 13: 9783319878102
Herausgeber: Hiromi Kubagawa/Peter D Burrows
Verlag: Springer Verlag GmbH
Umfang: ix, 117 S., 15 s/w Illustr., 15 farbige Illustr., 117 p. 30 illus., 15 illus. in color.
Erscheinungsdatum: 18.05.2018
Auflage: 1/2018
Produktform: Kartoniert
Einband: Kartoniert

This volume reviews the current state of research on the IgM antibody and its multiple receptors and binding proteins. Interactions of the IgM ligands with these molecules are important for protection against infections as a first line of defense, as well as for regulation of immune responses to pathogens and self-antigens. The book includes up-to-date information on: (i) the phylogeny of three IgM-binding receptors [polymeric Ig receptor (pIgR), Fc receptor for both IgA and IgM (Fca/µR), and Fc receptor for IgM only (FcµR)]; (ii) the lymphocyte-restricted distribution and unique ligand-binding activity of FcµR; (iii) the definition and potential function of Fc receptor-like molecule A (FCRLA) as a resident endoplasmic reticulum protein that binds IgM, but also IgG and IgA; (iv) IgM antibody-mediated enhancement of humoral immune responses, highlighting the importance of complement and its receptors, (v) the numerous important roles of IgM natural antibodies in regulation of inflammation. It is an invaluable resource for researchers and clinicians alike.

Artikelnummer: 6774635 Kategorie:

Beschreibung

Autorenporträt

Hiromi Kubagawa, MD, is presently Guest Senior Scientist at Deutsches Rheuma-Forschungszentrum, Berlin, Germany  Peter D. Burrows, PhD,  is a professor at Dept. of Microbiology, University of Alabama at Birmingham, AL, USA

Herstellerkennzeichnung:


Springer Verlag GmbH
Tiergartenstr. 17
69121 Heidelberg
DE

E-Mail: juergen.hartmann@springer.com

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