Produktbild: Hyperbranched Polydendrons

Hyperbranched Polydendrons

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A New Macromolecular Architecture, Springer Theses

ISBN: 3319369792
ISBN 13: 9783319369792
Autor: Hatton, Fiona L
Verlag: Springer Verlag GmbH
Umfang: xxii, 260 S., 209 s/w Illustr., 9 farbige Illustr., 260 p. 218 illus., 9 illus. in color.
Erscheinungsdatum: 09.10.2016
Auflage: 1/2015
Produktform: Kartoniert
Einband: Kartoniert

This thesis outlines the first synthesis of a new complex branched polymer architecture that aims to combine the benefits of dendrimers with the simplicity of conventional polymerisation. There is no other available literature on these remarkable materials, dubbed hyperbranched polydendrons, due to their novelty. The new materials were shown to have very high molecular weights (>1,000,000 g/mol), exceptional self-assembly and encapsulation behaviour and unparalleled functionalisation capabilities, and were studied pharmacologically to determine their potential as oral nanomedicine candidates. The detailed investigation of the chemical variables involved in synthesising hyperbranched polydendrons has shown that their self-assembly and pharmacological behaviour can be turned on and off and fine-tuned by altering the composition of the materials. The permeation of the self-assembled particles through model gut epithelium suggests the potential for oral dosing of drug loaded nanomedicines that result in circulating nanoparticles – a research goal that is currently being pursued by several groups around the globe.

Artikelnummer: 9930774 Kategorie:

Beschreibung

Autorenporträt

Dr. Fiona L. Hatton obtained a 1st class MChem degree in medicinal chemistry and pharmacology from the University of Liverpool, UK, 2010. She received her PhD in 2014 from the same university, under the supervision of Prof. Steve Rannard, specializing in polymer chemistry, more specifically hyperbranched polydendrons. Fiona joined the division of Coating Technology, KTH Royal Institute of Technology, Sweden in 2014 as a postdoctoral researcher working for associate professor Anna Carlmark.

Herstellerkennzeichnung:


Springer Verlag GmbH
Tiergartenstr. 17
69121 Heidelberg
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E-Mail: juergen.hartmann@springer.com

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