Developmental Plasticity of Inhibitory Circuitry

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ISBN: 1441912428
ISBN 13: 9781441912428
Herausgeber: Sarah L Pallas
Verlag: Springer Verlag GmbH
Umfang: xi, 190 S.
Erscheinungsdatum: 17.12.2009
Auflage: 1/2010
Produktform: Gebunden/Hardback
Einband: GEB

Neuroscience has long been focused on understanding neural plasticity in both development and adulthood. However, experimental work in this area has focused almost entirely on plasticity at excitatory synapses. A growing body of evidence suggests that plasticity at inhibitory GABAergic and glycinergic synapses is of critical importance during both development and aging. Only a few investigators have been engaged in research on how inhibitory circuits are formed during development or how they are involved in plasticity of developing sensory and motor circuitry. Developmental Plasticity of Inhibitory Circuitry approaches the subject of inhibitory plasticity from several levels of analysis, from synapses to circuits to systems to clinical, summarizing several possible mechanisms and collecting some of the most fascinating work in this under-studied area. It is meant to provide an overview for basic and clinical researchers and students interested in neural plasticity and to stimulate further research. About the Editor: Dr. Sarah L. Pallas is a Professor of Neuroscience and Biology at Georgia State University. She earned her Ph.D. in Neurobiology and Behavior at Cornell University, under the tutelage of Dr. Barbara Finlay. Her postdoctoral training was received at M.I.T. in the laboratory of Dr. Mriganka Sur. Her research concerns developmental neurobiology and sensory physiology, and in particular the role of sensory experience in the development and plasticity of neural circuits.

Artikelnummer: 1486289 Kategorie:

Beschreibung

InhaltsangabeThe Origins and Specification of Cortical Interneurons.- Role of Spontaneous Activity in the Maturation of GABAergic Synapses in Embryonic Spinal Circuits.- Regulation of Inhibitory Synapse Function in the Developing Auditory CNS.- Developmental Plasticity of Inhibitory Receptive Field Properties in the Auditory and Visual Systems.- Postnatal Maturation and Experience-Dependent Plasticity of Inhibitory Circuits in Barrel Cortex.- GABAergic Transmission and Neuronal Network Events During Hippocampal Development.- Endocannabinoids and Inhibitory Synaptic Plasticity in Hippocampus and Cerebellum.- Interneuron Pathophysiologies: Paths to Neurodevelopmental Disorders.

Inhaltsverzeichnis

History of the field.- Tools for the study of inhibitory plasticity.- Migratory pathways of inhibitory interneurons in cerebral cortex.- Changes in the function of GABAergic synapses during development.- Homeostatic plasticity of cortical circuits demonstrated in vitro and in vivo.- Role of spontaneous activity in the maturation of GABAergic synapses in spinal circuits.- Role of inhibitory plasticity in sound localization circuits.- Activity-dependent plasticity of inhibition underlying complex response properties in the visual and auditory systems.- Inhibitory circuits underlying critical period plasticity in visual cortex.- Endocannabinoids underlie inhibitory plasticity in the cerebellum and hippocampus.- Co-release of neurotransmitters as a mechanism for inhibitory plasticity.- LTD as a mechanism for inhibitory plasticity.- Developmental switches in GABAergic signalling as a mechanism for inhibitory plasticity.- What is the role of inhibitory plasticity in normal development and neurological disease.

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