Beschreibung
InhaltsangabePart I. Cytokine Knockouts in Models of Human Disease Cytokine Knockouts in Inflammation Pietro Ghezzi The Use of Cytokine Knockouts to Study Host Defense Against Infection Charles A. Dinarello The Use of Cytokine Knockouts in Animal Models of Autoimmune Disease Alfons Billiau, Hubertine Heremans, and Patrick Matthys The Use of Cytokine Knockout Mice in Cancer Research Robert H. Wiltrout, Jon M. Wigginton, and William J. Murphy The Use of Cytokine Knockout Mice in Neuroimmunology Giamal N. Luheshi, Emmanuel Pinteaux, and Hervé Boutin Part II. Cytokine Knockout Mice The Role of IL-1 in the Immune System Susumu Nakae, Reiko Horai, Yutaka Komiyama, Aya Nambu, Masahide Asano, Akio Nakane, and Yoichiro Iwakura IL1 Receptor AntagonistDeficient Mice Martin J. H. Nicklin and Joanna Shepherd A Unique Role for IL-2 in Self-Tolerance Thomas Hünig and Anneliese Schimpl Molecular Basis for Binding Multiple Cytokines by gc: Implications for X-SCID and Impaired gc-Dependent Cytokine Receptor Function Ferenc Olosz and Thomas R. Malek GCSF, GMCSF, and IL3 Knockout Mice Thomas Enzler and Glenn Dranoff IL4 Knockout Mice Pascale Kropf and Ingrid Müller Role of IL5 in Immune and Pathological Responses in the Mouse Paul S. Foster and Simon P. Hogan. IL-6 Knockout Mice, Valeria Poli and Diego Maritano IL10 and IL2 Knockout Mice: Effect on Intestinal Inflammation Karen L. Madsen and Humberto Jijon IL12Deficient Mice Luciano Adorini IL13 and Double IL4/IL13 Knockout Mice Duncan R. Hewett and Andrew N. J. McKenzie IL15: Insights from Characterizing IL15Deficient Mice Pallavur V. Sivakumar, Sandra N. Brown, Ananda W. Goldrath, Anne Renee Van der Vuurst de Vries, Joanne L. Viney, and Mary K.Kennedy IL18 and IL18 Receptor Knockout Mice Hiroko Tsutsui, Tomohiro Yoshimoto, Haruki Okamura, Shizuo Akira, and Kenji Nakanishi Mice Knockouts for Chemokines and Chemokine Receptors Jane M. Schuh, Steven L. Kunkel, and Cory M. Hogaboam IFNg and IFNg Receptor Knockout Mice, Dyana Dalton Macrophage Migration Inhibitory Factor (MIF)-Deficient Mice Gunter Fingerle-Rowson, Abhay R. Satoskar, Richard Bucala Osteopontin, a Surprisingly Flexible Cytokine: Functions Revealed from Osteopontin Knockout Mice Susan R. Rittling, Anthony W. O'Regan, and Jeffrey S. Berman RANKL, RANK, and OPG YoungYun Kong and Josef M. Penninger Targeting the TGF-b Pathway In Vivo: Defining Complex Roles for TGF-b Signaling in Immune Function, Wound Healing, and Carcinogenesis Lawrence Wolfraim, Mizuko Mamura, Anita Roberts, and John J. Letterio Physiologic Roles of Members of the TNF and TNF Receptor Families as Revealed by Knockout Models Sergei A. Nedospasov, Sergei I. Grivennikov, and Dmitry V. Kuprash Index
Inhaltsverzeichnis
Part I. Cytokine Knockouts in Models of Human Disease Cytokine Knockouts in Inflammation Pietro Ghezzi The Use of Cytokine Knockouts to Study Host Defense Against Infection Charles A. Dinarello The Use of Cytokine Knockouts in Animal Models of Autoimmune Disease Alfons Billiau, Hubertine Heremans, and Patrick Matthys The Use of Cytokine Knockout Mice in Cancer Research Robert H. Wiltrout, Jon M. Wigginton, and William J. Murphy The Use of Cytokine Knockout Mice in Neuroimmunology Giamal N. Luheshi, Emmanuel Pinteaux, and Herve Boutin Part II. Cytokine Knockout Mice The Role of IL-1 in the Immune System Susumu Nakae, Reiko Horai, Yutaka Komiyama, Aya Nambu, Masahide Asano, Akio Nakane, and Yoichiro Iwakura IL-1 Receptor Antagonist-Deficient Mice Martin J. H. Nicklin and Joanna Shepherd A Unique Role for IL-2 in Self-Tolerance Thomas Hünig and Anneliese Schimpl Molecular Basis for Binding Multiple Cytokines by gc: Implications for X-SCID and Impaired gc-Dependent Cytokine Receptor Function Ferenc Olosz and Thomas R. Malek G-CSF, GM-CSF, and IL-3 Knockout Mice Thomas Enzler and Glenn Dranoff IL-4 Knockout Mice Pascale Kropf and Ingrid Müller Role of IL-5 in Immune and Pathological Responses in the Mouse Paul S. Foster and Simon P. Hogan. IL-6 Knockout Mice, Valeria Poli and Diego Maritano IL-10 and IL-2 Knockout Mice: Effect on Intestinal Inflammation Karen L. Madsen and Humberto Jijon IL-12-Deficient Mice Luciano Adorini IL-13 and Double IL-4/IL-13 Knockout Mice Duncan R. Hewett and Andrew N. J. McKenzie IL-15: Insights from Characterizing IL-15-Deficient Mice Pallavur V. Sivakumar, Sandra N. Brown, Ananda W. Goldrath, Anne Renee Van der Vuurst de Vries, Joanne L. Viney, and Mary K. Kennedy IL-18 and IL-18 Receptor Knockout Mice Hiroko Tsutsui, Tomohiro Yoshimoto, Haruki Okamura, Shizuo Akira, and Kenji Nakanishi Mice Knockouts for Chemokines and Chemokine Receptors Jane M. Schuh, Steven L. Kunkel, and Cory M. Hogaboam IFN-g and IFN-g Receptor Knockout Mice, Dyana Dalton Macrophage Migration Inhibitory Factor (MIF)-Deficient Mice Gunter Fingerle-Rowson, Abhay R. Satoskar, Richard Bucala Osteopontin, a Surprisingly Flexible Cytokine: Functions Revealed from Osteopontin Knockout Mice Susan R. Rittling, Anthony W. O''Regan, and Jeffrey S. Berman RANKL, RANK, and OPG Young-Yun Kong and Josef M. Penninger Targeting the TGF-b Pathway In Vivo: Defining Complex Roles for TGF-b Signaling in Immune Function, Wound Healing, and Carcinogenesis Lawrence Wolfraim, Mizuko Mamura, Anita Roberts, and John J. Letterio Physiologic Roles of Members of the TNF and TNF Receptor Families as Revealed by Knockout Models Sergei A. Nedospasov, Sergei I. Grivennikov, and Dmitry V. Kuprash Index
