Beschreibung
In the last decade, focus of the researchers working in the field of cancer biology has shifted from the genetic defects to epigenetic dysregulation, especially that of non-coding RNAs (ncRNAs). This book encompasses a comprehensive review of the transcriptional landscape of the cell and its involvement in the cancer pathophysiology. The first two chapters of the book will elucidate the basics of biosynthesis, mechanism of action and modulation of the epigenetic regulation of gene expression by both coding as well as non-coding RNAs. The third chapter will discuss the aberrant expression of the cellular RNome in the cancer cells and highlight its role in the orchestration of processes involved in evolution as well as sustenance of the cancer cells. Finally, the last chapter will discuss the recent progress in the field of translating the transcriptome into diagnostic/prognostic biomarkers and as targets for novel anti-cancer therapies. The book provides an insight to the field of RNome in context of cancer and will be helpful to students, researchers and clinicians.
Autorenporträt
Dr. Deepak Kaul is currently working as Professor & Head at Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. He has done his PhD from the prestigious All India Institute of Medical Sciences (AIIMS) New Delhi. He is also founder of the Molecular Biology Unit at PGIMER. He has been associated with PGIMER for more than three decades. His main area of research is Molecular Medicine, Functional Genomics, Genomic-Immunity and Cancer biology. Dr. Kaul has published over 150 papers which speaks the volume of his contributions made in the field. Dr. Kaul is fellow/member of various prestigious international societies such as Fellow, Royal College of Pathologists (London); Fellow, Indian National Science Academy (India); Fellow, International College of Angiology; Member, New York Academy of Sciences; Member, Biochemical Society, London; etc. He is in editorial board of several reputed international journals such Journal of Anti-virals & Anti-retrovirals, Word Journal of Cardiology, World Journal of Immunology, Leukemia Research, Molecular & Cellular Biochemistry, etc. He is also expert member of several task force and committees of Government of India such as Task-Forces on "RNA-Interference" & "Biology of Infectious Diseases", Department Of Biotechnology, Ministry of Science & Technology, Govt. of India. Dr. Mansi Arora is currently working as a Jr. Demonstrator at Department of Experiment Medicine and Biotechnology, PGIMER. She completed her PhD from the same institute in 2014 and since then she has been working as Jr. Demonstrator there. In a relatively very short span of scientific career she has published 5 papers and has presented work at several reputed international/ national conferences and symposia.
Herstellerkennzeichnung:
Springer Verlag GmbH
Tiergartenstr. 17
69121 Heidelberg
DE
E-Mail: juergen.hartmann@springer.com
