Produktbild: Antibody-Drug Conjugates

Antibody-Drug Conjugates

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Methods and Protocols, Methods in Molecular Biology 2078

ISBN: 1493999281
ISBN 13: 9781493999286
Herausgeber: L Nathan Tumey
Verlag: Springer Verlag GmbH
Umfang: xi, 373 S., 29 s/w Illustr., 109 farbige Illustr., 373 p. 138 illus., 109 illus. in color.
Erscheinungsdatum: 24.10.2019
Auflage: 1/2020
Produktform: Gebunden/Hardback
Einband: Gebunden

This volume looks at key methodologies that are commonly used across antibody drug conjugates (ADCs) programs. The chapters in this book cover topics such as conjugations to endogenous cysteine residues; click chemistry conjugations; antibody conjugations via glycosyl remodeling; analysis of ADCs by native mass spectrometry; characterization of ADCs by capillary electrophoresis; LC/MS methods for studying lysosomal ADC catabolism; and determination of ADC concentration by ligand-binding assays. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Antibody-Drug Conjugates: Methods and Protocols is a valuable resource that aims to lower the „activation barrier“ when undertaking a new discipline, and provides a „toolbox“ for the next generation of ADC scientists.

Artikelnummer: 7818280 Kategorie:

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