Progranulin and Central Nervous System Disorders

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106,99 

ISBN: 9811361851
ISBN 13: 9789811361852
Herausgeber: Hideaki Hara/Masato Hosokawa/Shinsuke Nakamura et al
Verlag: Springer Verlag GmbH
Umfang: vii, 183 S., 24 s/w Illustr., 13 farbige Illustr., 183 p. 37 illus., 13 illus. in color.
Erscheinungsdatum: 02.04.2019
Auflage: 1/2019
Produktform: Gebunden/Hardback
Einband: Gebunden

This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students.

Artikelnummer: 6131019 Kategorie:

Beschreibung

Autorenporträt

Hideaki Hara, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Japan Masato Hosokawa, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Japan Shinsuke Nakamura, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Japan Takayoshi Shimohata, Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Japan Masugi Nishihara, Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan

Herstellerkennzeichnung:


Springer Verlag GmbH
Tiergartenstr. 17
69121 Heidelberg
DE

E-Mail: juergen.hartmann@springer.com

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