Beschreibung
Twenty years have passed since I became a professor in the First Department of Pathology, Hiroshima University School of Medicine. It is my great pleas ure that Molecular Pathology o[ Gastroenterological Cancer-Application to Clinical Practice has been published by Springer-Verlag Tokyo to commemo rate the 20th anniversary of my professorship. Seeing the academic achievements of our department during these 20 years, I am confident that we could establish a department of oncology to research the pathogenesis of human cancer through systemic application of a variety of molecular techniques. We have demonstrated that the develop me nt and progression of esophageal, gastric, and colon cancer require mul tiple alterations affecting DNA mismatch repair genes, oncogenes, and tumorsuppressor genes, and that common and uncommon genetic changes exist for esophageal, gastric, and colorectal carcinomas. In addition to these genetic changes, the majority of gastrointestinal cancers express telomerase activity, with overexpression of telomerase RNA, indicating a powerful addi tional tool for early detection of gastrointestinal cancer. By transferring these basic observations to the clinic, we now are able to make accurate cancer diagnoses, thus determing the grade of malignancy and patient prognosis. We also can identify patients at high risk for developing cancer and create new therapeutic approaches. In fact, we have routinely implemented a new molecular diagnosis strategy at the Hiroshima City Medi cal Association Clinical Laboratory since August 1993.
Inhaltsverzeichnis
InhaltsangabeExperimental Stomach Carcinogenesis.- Multistep Carcinogenesis of Esophageal Carcinoma.- Oxidative Damage During the Gastric Precancerous Process.- Multiple Genetic Alterations and Abnormal Growth Factor Network in Human Esophageal Carcinomas.- Genetic Alterations in the Precursors of Gastric Cancer.- Molecular Bases of Human Stomach Carcinogenesis.- Galectins in Gastric and Colorectal Cancers: Implications for Tumor Progression and Metastasis.- Stomach Cancer and Apoptosis: A Review.- Pathogenesis of Serrated Adenoma of the Colorectum: Implication for Malignant Progression.- Carcinoma Cells at Deeply Infiltrated Sites: Role in Development of Metastases in Patients with Advanced Colorectal Adenocarcinomas.- Glycoprotein Histochemistry and the Histogenesis of Colorectal Cancer.- Critical Determinants of Human Colon Cancer Metastasis.- Abnormal CD44 Gene Expression in Neoplasia: Biological and Clinical Implications.- Molecular Diagnosis of Gastrointestinal Cancer.- Interactive Effects of p53 Tumor Suppressor Gene and Hepatitis B Virus in Hepatocellular Carcinogenesis.- Molecular Genetics of Hepatocellular Carcinoma.- Telomeres and Telomerase in Gastrointestinal Cancers.- Contributor Index.
