Beschreibung
The dogmas of the quiet past are inadequate to the stormy present. The occasion is piled high with difficulty, and we must rise with the occasion. As our case is new, so we must think anew and act anew. Abraham Lincoln, 1862 When I came across this quote, it made me recall my first participation at an international meeting on bone marrow transplantation, at a time when this was the only term that was used to describe the field. During a particular session there was a presentation on the use of peripheral blood as the sole source of stem cells for transplantation, and a member of the audience rose to state that it was medically unethical to consider such treatment, as it certainly could not contain stem cells. Now nearly twenty years later, peripheral blood is the predominant source of stem cells used for hematopoietic stem cell transplantation. In the same period of time there have been several other dogmatic opinions, which permeate all of medicine, that have come and gone in the field of hematopoietic stem cell transplantation, and will continue to do so with advancements from basic and clinical research. It is within this context that the format of this book was devised. Traditionally reviews on specific topics related to hematopoietic stem cell transplantation reflect the views of a single author or a research group.
Inhaltsverzeichnis
Principles and overview of allogeneic hematopoietic stem cell transplantation.- Principles and overview of autologous hematopoietic stem cell transplantation.- Natural killer cell activity and killer immunoglobulin-like receptors in hematopoietic stem cell transplantation.- Advancement and clinical implications of HLA typing in allogeneic hematopoietic stem cell transplantation.- Immunogenomics and proteomics in hematopoietic stem cell transplantation.- Clinical implications of immune reconstitution following autologous and allogeneic hematopoietic stem cell transplantation.- T-regulatory cells and T cell cytokines in hematopoietic stem cell transplantation.- Understanding and enhancing the graft-versus-leukemia effect after hematopoietic stem cell transplantation.- Non-myeloablative and reduced-intensity allogeneic hematopoietic stem cell transplantation.- Cord blood transplantation.- Bone marrow and peripheral blood stem cell transplantation from unrelated donors.- Biology and management of acute graft-versus-host disease.- Biology and management of chronic graft-versus-host disease.- Radio-immunoconjugates in hematopoietic stem cell transplantation.- Evolving indications for hematopoietic stem cell transplantation in multiple myeloma and other plasma cell disorders.- Role of hematopoietic stem cell transplantation in the treatment of non-Hodgkin¿s lymphomas.- Role of hematopoietic stem cell transplantation in the treatment of Hodgkin¿s disease.- Role of hematopoietic stem cell transplantation in acute myelogenous leukemia.- Role of hematopoietic stem cell transplantation in acute myelogenous leukemia.- Hematopoietic stem cell transplantation in the management of pediatric malignancies.- Cellular adoptive immunotherapy after autologous and allogeneic hematopoietic stem cell transplantation.- Improvements in the prevention and management of infectious complications after hematopoietic stem cell transplantation.
