Beschreibung
Inhaltsangabe1 Neuroendocrinology.- 1.1. Introduction.- 1.2. Biosynthesis of CNS Peptides.- 1.2.1. ACTH and Related Peptides in Brain.- 1.2.2. Vasopressin, Oxytocin, and Neurophysins.- 1.2.3. Somatostatin.- 1.3. Extrahypothalamic Localization of "Hypothalamic Releasing Factors" and Peptides.- 1.3.1. ACTH.- 1.3.2. Vasopressin.- 1.3.3. Somatostatin.- 1.3.4. Gonadotropin-Releasing Hormone (LHRH).- 1.3.5. Thyrotropin-Releasing Hormone.- 1.4. Possible Functional Homeostatic Significance of Brain Peptides.- 1.4.1. Cognitive Behavior.- 1.4.2. Effects on Feeding.- 1.5. Possible Functions of Opioid-like Peptides.- 1.5.1. On Prolactin Release.- 1.5.2. In Clinical Syndromes.- 1.6. Results of Transsphenoidal Hypophysectomy for Hyperfunctioning Pituitary Adenomas.- 1.6.1. Acromegaly.- 1.6.2. Prolactinomas.- 1.6.3. Cushing's Disease.- References.- 2 Prolactin and Growth Hormone in Health and Disease.- 2.1. Introduction.- 2.2. Prolactin.- 2.2.1. The Prolactin Gene and mRNA.- 2.2.2. Prolactin Molecular Heterogeneity.- 2.2.3. Amniotic Fluid Prolactin.- 2.2.4. Pituitary Prolactin Secretion in Pregnancy.- 2.2.5. Physiologic Secretion of Prolactin and Functional Abnormalities.- 2.2.6. Hyperprolactinemia in Uremia.- 2.2.7. Prolactin Effects on Androgens.- 2.2.8. Effects of Pharmacologic Agents on Prolactin Secretion.- 2.2.9. Provocative Tests of Prolactin Secretion.- 2.2.10. Etiology of Prolactinomas.- 2.2.11. Hypothalamic Function Associated with Prolactinoma.- 2.2.12. Clinical Manifestations of Prolactinomas.- 2.2.13. Diagnosis of Prolactinomas.- 2.2.14. Pituitary Function in Patients with Prolactinoma.- 2.2.15. Treatment with Dopaminergic Agents.- 2.2.16. Neurosurgical Treatment.- 2.3. GH.- 2.3.1. GH Genes and mRNA.- 2.3.2. GH Heterogeneity.- 2.3.3. Homologous Radioreceptor Assays for hGH.- 2.3.4. GH Regulation by Somatostatin.- 2.3.5. GH Regulation by Somatocrinin (GHRH).- 2.3.6. GH Regulation in Men.- 2.3.7. GH Effects on Calcium and Phosphorus Metabolism.- 2.3.8. Pituitary Pathology in Acromegaly.- 2.3.9. Control of GH Secretion in Acromegaly.- 2.3.10. Disturbed Organ Physiology in Acromegaly.- 2.3.11. Diabetes and Acromegaly.- 2.3.12. Treatment of Acromegaly.- 2.4. Hypopituitarism.- 2.4.1. Etiology.- 2.4.2. Familial Isolated GH Deficiency.- 2.4.3. Hormonal Studies in Hypopituitary Children.- 2.4.4. GH Treatment.- 2.4.4.1. GH Refractoriness.- 2.5. Somatomedins.- 2.5.1. Structure.- 2.5.2. Measurement of Somatomedins.- 2.5.3. Somatomedin-Binding Proteins of Serum.- 2.5.4. Variation in Normal Serum Somatomedin Levels.- 2.5.5. Somatomedin Levels in Malnutrition and Uncontrolled Diabetes Mellitus.- 2.5.6. Somatomedins in Chronic Renal Failure.- 2.5.7. Somatomedin Levels in Hypopituitarism.- References.- 3 The Thyroid.- 3.1. Hypothalamic-Pituitary-Thyroid Interrelationships.- 3.2. Thyroid Hormone and Thyroglobulin Synthesis and Release.- 3.3. Peripheral Metabolism, Action, and Serum Protein Binding of the Thyroid Hormones.- 3.4. Fetal and Neonatal Thyroid Function.- 3.5. Hyperthyroidism.- 3.6. Hypothyroidism.- 3.7. Nontoxic Goiter.- 3.8. Thyroid Carcinoma.- 3.9. Miscellaneous.- References.- 4 The Testis.- 4.1. Introduction.- 4.2. Intrauterine and Neonatal Function.- 4.2.1. Embryonic Sex Differentiation.- 4.2.1.1. Normal Controls.- 4.2.1.2. Defects in Fetal Sex Differentiation.- 4.2.2. Testicular Function in Childhood.- 4.3. Puberty.- 4.4. Adult Physiology.- 4.4.1. The Hypothalamus and Pituitary.- 4.4.2. The Testis.- 4.4.2.1. Steroidogenesis.- 4.4.2.2. Spermatogenesis.- 4.4.2.3. Effect of Age.- 4.5. Adult Pathophysiology.- 4.5.1. Gonadotropin Deficiencies.- 4.5.2. The Testis.- 4.5.2.1. Steroidogenesis.- 4.5.2.2. Tubular Defects.- 4.6. Effect of Systemic Disease on Gonadal Function.- 4.7. Testicular Tumors.- 4.8. Miscellaneous.- 4.8.1. Gynecomastia.- 4.8.2. Impotence.- References.- 5 Aldosterone and Renin.- 5.1. A Reexamination and Further Definition of Congenital Adrenal Hyperplasia through the Examination of Steroids in the Mineralocorticoid Hormone Pathways.-
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