Beschreibung
InhaltsangabeI. Relation Between Arterial Wall and Risk Factors for Coronary Heart Disease Connective Tissue and Immunological Mechanism on Atherosclerosis.- Arterial Endothelial Permeability to Macromolecules.- The Maintenance of Endothelial Integrity.- Arterial Smooth Muscle Cells in Atherogenesis: Births, Deaths and Clonal Phenomena.- Lipoproteins - Steady State Aspects.- Connective Tissue in Atherosclerosis.- Immunologic Mechanism of Atherosclerosis.- Workshop 1. Dynamics of Lipoproteins and Lipids in the Arterial Wall.- Uptake of Serum Lipoproteins into the Arterial Wall.- Enzymes Catalyzing Phospholipid-Dependent Transacylations in the Arterial Wall.- Heparin-Manganese Precipitability of Canine Lipoproteins as Correlated With Binding to the Cell Surface Receptors on Fibroblasts.- Synthesis and Removal of Free Cholesterol and of Cholesterol Ester by Smooth Muscle Cells in Tissue Culture.- Abstracts.- Workshop 2. Hypertension, Arteriolar Disease and Atherosclerosis.- Possibilities of Hyaline Formation in the Vessel Wall, Light- and Electron Microscopic Structure: Problems of the Nomenclature.- Hypertension, Stroke and Atherogenesis in Experimental Models.- Hypertension and Cerebral Atherosclerosis.- Abstracts.- Workshop 3. Epidemiology of Atherosclerosis and Geographic Differences in Risk Factors.- An Introduction to the Epidemiology of Atherosclerosis.- Association Between Risk Factors and Atherosclerotic Lesions Based on Autopsy Findings in the Oslo Study: A Preliminary Report.- Atherosclerosis and Risk Factors.- Coronary Risk Factors in Adults: The Influence of Nutrition in Early Life.- The Relation of Ante Mortem Factors to Atherosclerosis at Necropsy.- Atherosclerosis and Its Risk Factors in the Hawaiian Japanese.- Atherosclerosis in Relation to Personal Attributes of a Japanese Population in Homes for the Aged.- Frequency of Coronary and Peripheral Artery Disease in Hyperlipoproteinemia.- Concluding Remarks on the Epidemiology of Atherosclerosis.- Abstracts.- Workshop 4. Measurement of Triglyceride Turnover.- Kinetics of VLDL Subfractions.- Comparison of Methods of Plasma Triglyceride Turnover.- The Intravenous Fat Tolerance Test With Intralipid-Validity, Applications, and Limitations.- Triglyceride Turnover in Diabetic States of Dogs.- Abstracts.- Workshop 5. Smoking and Atherosclerosis.- Epidemiological Research in Japan on Smoking and Cardiovascular Diseases.- Atherogenic Compounds of Tobacco Smoke.- Abnormalities Potentially Mediating the Effect of Cigarette Smoking on Atherosclerosis.- Oxygen Transport and Smoking.- The Evidence for Nicotine as an Etiological Factor in Cardiovascular Disease (CVD).- Abstracts.- II. Lipoproteins.- Structure of the Plasma Lipoproteins - A Review.- Cellular Catabolism of Serum Lipoproteins.- Synthesis and Secretion of Plasma Lipoproteins and Apo-Lipoproteins.- Dynamics of Lipoprotein Interconversion.- Lipoprotein Metabolism in Tissue Culture.- Current Concepts of Hyperlipoproteinemia.- Workshop 6. Lipoproteins.- Electroimmunoassays of Serum Apolipoproteins in Normolipidemic Subjects and Patients With Primary Hyperlipoproteinemias.- Lipid Organization in Human Plasma Low-Density Lipoproteins.- Formation and Structural Properties of Lipoprotein-X.- Isothermal Calorimetric Studies on Human HDL Apolipoproteins.- High-Density Lipoprotein Abnormalities Associated With Disease.- On the Role of Apolipoprotein A-I in the Structure of Serum High-Density Lipoproteins (HDL).- Abstracts.- Workshop 7. Animal Models of Atherosclerosis and Regression.- Requirement for Regression Studies in Animal Models.- The Effect of Strenuous Exercise on Plasma Lipids and Atherosclerosis on Cholesterol-Fed Cockerels.- Changes of Cyclic Nucleotides in the Regressive Course of Experimental Atherosclerosis and Their Modification by Sex Hormones and Phthalazinol.- Model of Arterial Injury by Balloon De-Endothelialization: Reappraisal, Improvement, and Application to Measurement of Endothelial Growth.- Reversibility of Atheroscl
The presence of monotypism in thick atherosclerotic lesions of black females with G-6-PD mosaicism first reported by the Benditts (1973) has been confirmed in two other laboratories. However, we believe that it is premature to conclude that the finding of monotypism necessarily indicates monoclonal origin of athero sclerotic lesions. We have suggested two alternative explanations for the obser vation of monotypism which we believe must be shown to be invalid before accept ing monoclonal origin as the only plausible way to account for the observed G-6-PD monotypism. One of these two alternatives relates to clonal heterogeneity of cell growth potential, i. e., during the course of progressive growth of a le sion, progeny of one cell may overgrow all others in a portion of the lesion. The other alternative is that one of the G-6-PD alleles may be linked to genes that afford a preferential survival characteristic in the abnormal environment present in atheroscerotic lesions. Thus, cells with one allele may be able to grow better than cells with the other allele, and this characteristic may be unrelated to "A-ness" or "B-ness". We have studied initiation of lesions in He diet-fed swine and demonstrated that all active lesions that were studied were of multiple cell origin (not monoclo nal). We have studied cell growth patterns in developing atherosclerotic lesions in He diet-fed swine and found evidence consistent with clonal heterogeneity in growth potential of lesion cells.
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E-Mail: juergen.hartmann@springer.com
