Produktbild: Data Analytics for Protein Crystallization

Data Analytics for Protein Crystallization

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106,99 €

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Computational Biology 25

ISBN: 3319589369
ISBN 13: 9783319589367
Autor: Pusey, Marc L/Aygün, Ramazan Savas
Verlag: Springer Verlag GmbH
Umfang: xx, 231 S., 10 s/w Illustr., 56 farbige Illustr., 231 p. 66 illus., 56 illus. in color.
Erscheinungsdatum: 13.12.2017
Auflage: 1/2018
Produktform: Gebunden/Hardback
Einband: Gebunden

This unique text/reference presents an overview of the computational aspects of protein crystallization, describing how to build robotic high-throughput and crystallization analysis systems. The coverage encompasses the complete data analysis cycle, including the set-up of screens by analyzing prior crystallization trials, the classification of crystallization trial images by effective feature extraction, the analysis of crystal growth in time series images, the segmentation of crystal regions in images, the application of focal stacking methods for crystallization images, and the visualization of trials. Topics and features: Describes the fundamentals of protein crystallization, and the scoring and categorization of crystallization image trials Introduces a selection of computational methods for protein crystallization screening, and the hardware and software architecture for a basic highthroughput system Presents an overview of the image features used in protein crystallization classification, and a spatiotemporal analysis of protein crystal growth Examines focal stacking techniques to avoid blurred crystallization images, and different thresholding methods for binarization or segmentation Discusses visualization methods and software for protein crystallization analysis, and reviews alternative methods to Xray diffraction for obtaining structural information Provides an overview of the current challenges and potential future trends in protein crystallization This interdisciplinary work serves as an essential reference on the computational and data analytics components of protein crystallization for the structural biology community, in addition to computer scientists wishing to enter the field of protein crystallization. Dr. Marc L. Pusey is a Research Scientist at iXpressGenes, Inc. Huntsville, AL, USA. Dr. Ramazan Savas Aygün is an Associate Professor in the Computer Science Department of the University of Alabama in Huntsville, USA.

Artikelnummer: 2276602 Kategorie:

Beschreibung

Presents an overview of computational aspects of protein crystallizationReviews computational methods for protein crystallization screeningDiscusses the effective scoring of protein crystallization trial imagesExamines the image processing of crystallization trial images Describes the spatiotemporal analysis of protein crystal growth

Autorenporträt

Dr. Marc L. Pusey is a Research Scientist at iXpressGenes, Inc., Huntsville, AL, USA. Dr. Ramazan S. Aygün is an Associate Professor in the Computer Science Department of the University of Alabama in Huntsville, USA.

Herstellerkennzeichnung:


Springer Verlag GmbH
Tiergartenstr. 17
69121 Heidelberg
DE

E-Mail: juergen.hartmann@springer.com

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