Beschreibung
In this study, the physiological and molecular effects of two cholesterol lowering agents, synthetic statin (atorvastatin) and natural statin (simvastatin) on diabetic and hypercholesterolemic adult male Wistar albino rats (Rattus norvegicus)at two doses, 10 and 40 mg/kg, for 8 weeks was investigated. Other physiological parameters were evaluated under this investigation, like: glucose, urea, uric acid, creatinine, total protein, albumin, globulin, A/G ratio, total, direct and indirect billirubin) To assess the beneficial effect of the drugs on liver genomic DNA, the (RE) analysis with 5 restriction endonucleases manifested variations in DNA digestion patterns in diabetic and hypercholesterolemic rats treated with atorvastatin and simavstatin. Such variation reflects and clarifies a restoration and repairing effect of statin on rat liver DNA in diabetic and hypercholesterolemic rats.
Autorenporträt
Prof. Mohamed Sayed Salama,Prof.Nadia El-Beih and Dr.Enas Ali are a research team from the Faculty of Science, Ain Shams University (ASU). They had a history of research work in the field of molecular physiology on experimental animals. Their research work is highly recognized by their collegues nationally and regionally.
