Beschreibung
This book presents information regarding Mesenchymal Stem Cells (MSCs) as a source of immunomodulatory molecules which enables current and future researchers to consider, for example, how these MSCs could be employed to more precisely define the signal transduction mechanisms underlying the ability of these cells to suppress immune-mediated inflammation. It also further defines the methodologies required to transform the information gleaned from studies of MSC in vitro to well-validated preclinical animal models such as those that have proven to serve as replicas of autoimmunity and pre-term labor to name only two of the many animal models that are included. Beginning with an overview chapter which summarizes the major concepts and future perspectives, this essential volume brings together applications across autoimmune diseases such as SLE, rheumatoid arthritis and multiple sclerosis; blood cancers such as leukemia and lymphoma and reproductive biology where we will examine the relatively novel paradigm of potentially using MSCs in vitro and in animal models of pre-term labor to discover how these cells may eventually be clinically employed to suppress the inflammatory response that drives pre-term labor activity.
Autorenporträt
Charles J. Malemud received his Ph.D. from George Washington University and completed his postdoctoral studies at the State University of New York at Stony Brook. Since then, Dr. Malemud has been a member of the faculty at Case Western Reserve University School of Medicinewhere he is presently Professor of Medicine & Anatomy in the Division of Rheumatic Diseases and Senior Investigator in the Arthritis Research Laboratory. He has published over 200 papers, chapters and reviews primarily in the field of chondrocyte biology. Professor Malemud is on the editorial board of several rheumatology, immunology and musculoskeletal journals and serves as Editor-in-Chief of two of them. Eben Alsberg received his Ph.D. from the University of Michigan, Ann Arbor, and was a postdoctoral researcher at Harvard Medical School. He is currently a professor of Biomedical Engineering and Orthopaedic Surgery at Case Western Reserve University and also serves as Director of the Stem Cell and Engineered Novel Therapeutics Laboratory. He was a Lady Davis Fellow at the Technion (Israel), and he is currently an International Scholar (Visiting Professor) at Kyung Hee University (Korea). His lab focuses on the engineering of new technologies to regenerate tissues and treat diseases through the development of novel biomaterials and microenvironments. He has co-authored over 90 peer reviewed papers and book chapters. His work has been recognized with the 2008 Ellison Medical Foundation New Scholar in Aging Award and the Crain's Cleveland Business 2009 Forty Under 40 Award, and he was elected to the American Institute for Medical and Biological Engineering (AIMBE) College of Fellows. He is on the editorial board of several tissue engineering and biomaterials journals, and multiple government agencies and foundations have supported his lab's research.
